This site uses cookies to measure how you use the website so it can be updated and improved based on your needs and also uses cookies to help remember the notifications you’ve seen, like this one, so that we don’t show them to you again. If you could also tell us a little bit about yourself, this information will help us understand how we can support you better and make this site even easier for you to use and navigate.

CSF α-synuclein concentrations do not fluctuate over hours and are not correlated to amyloid β in humans


Spies, Petra E., Slats, Diane, Olde Rikkert, Marcel G. M., Tseng, Jack, Claassen, Jurgen A. H. R., Verbeek, Marcel M.


Neuroscience Letters, Volume: 504, No.: 3, Pages.: 336-338

Year of Publication



Reports on the value of cerebrospinal fluid (CSF) α-synuclein as a biomarker for dementia with Lewy bodies and Parkinson disease are contradicting. This may be explained by fluctuating CSF α-synuclein concentrations over time. Such fluctuations have been suggested for CSF amyloid β concentrations. Furthermore, a physiological relationship between α-synuclein and amyloid β has been suggested based on in vitro research. We performed repeated CSF sampling in healthy elderly and AD patients and showed that sinusoidal fluctuations in CSF α-synuclein concentrations were not present. Furthermore, we did not find evidence for an interaction between amyloid β and α-synuclein concentrations in CSF.; Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

Bibtex Citation

@article{Spies_2011, doi = {10.1016/j.neulet.2011.09.063}, url = {}, year = 2011, month = {oct}, publisher = {Elsevier {BV}}, volume = {504}, number = {3}, pages = {336--338}, author = {Petra E. Spies and Diane Slats and Marcel G.M. Olde Rikkert and Jack Tseng and Jurgen A.H.R. Claassen and Marcel M. Verbeek}, title = {{CSF} $upalpha$-synuclein concentrations do not fluctuate over hours and are not correlated to amyloid $upbeta$ in humans}, journal = {Neuroscience Letters} }


aged, aging, alphasynuclein, alzheimer disease, cerebrospinal fluid, diagnosis, female, humans, male, middle aged, models biological, peptide fragments, time factors

Countries of Study


Types of Dementia

Lewy-Body, Parkinson’s Dementia

Types of Study

Randomised Controlled Trial

Type of Outcomes


Type of Interventions

Diagnostic Target Identification

Diagnostic Targets

Biological Testing