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Cognitive effects of quetiapine in a patient with dementia with Lewy bodies

Authors

RICE, Timothy, DOBRY, Yuriy, WANG, Eugene, NOVAKOVIC, Vladan, SHER, Leo

Journal

Psychogeriatrics, Volume: 13, No.: 1, Pages.: 52-57

Year of Publication

2013

Abstract

A recent large-scale randomized controlled clinical trial, the Clinical Antipsychotic Trials of Intervention Effectiveness-Alzheimer’s Disease study, found a significant worsening of cognitive functioning in a sample of patients with Alzheimer’s disease. To date there have been no equally powered studies examining the cognitive effects of atypical antipsychotics in patients with dementia with Lewy bodies, the second most prevalent neurodegenerative disorder. This case report describes a significant cognitive improvement observed through the use of an atypical antipsychotic in a patient with dementia with Lewy bodies. The observed divergence in cognitive responsiveness is discussed mechanistically on both the clinical and neuromolecular level. Limitations to this case study design are presented and discussed. The prudence of caution in importing the results of the Clinical Antipsychotic Trials of Intervention Effectiveness-Alzheimer’s Disease study to the dementia with Lewy bodies population is summarized and presented for psychiatrists, neurologists and primary care providers, with an intent to stimulate discussion and further research. (PsycINFO Database Record (c) 2013 APA, all rights reserved). (journal abstract)

Bibtex Citation

@article{RICE_2013, doi = {10.1111/j.1479-8301.2012.00414.x}, url = {http://dx.doi.org/10.1111/j.1479-8301.2012.00414.x}, year = 2013, month = {mar}, publisher = {Wiley-Blackwell}, volume = {13}, number = {1}, pages = {52--57}, author = {Timothy RICE and Yuriy DOBRY and Eugene WANG and Vladan NOVAKOVIC and Leo SHER}, title = {Cognitive effects of quetiapine in a patient with dementia with Lewy bodies}, journal = {Psychogeriatrics} }

Keywords

alzheimer’s disease, antipsychotics, case, cognitive ability, cognitive effects, dementia with lewy bodies, drug therapy, quetiapine, quetiapine effects, study

Countries of Study

USA

Types of Dementia

Lewy-Body

Types of Study

Other

Type of Outcomes

Cognition

Type of Interventions

Pharmaceutical Interventions

Pharmaceutical Interventions

Antipsychotics and antidepressants