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Cognitive dysfunction in SLE: development of a screening tool


Adhikari, T., Piatti, A., Luggen, M.


Lupus, Volume: 20, No.: 11, Pages.: 1142-1146

Year of Publication



Background: Cognitive dysfunction (CD) is among the most common neuropsychiatric manifestations of systemic lupus erythematosus (SLE). There are two methods which have been used to detect CD in patients with SLE: traditional neuropsychological tests (NPT) and the Automated Neuropsychological Assessment Metrics (ANAM). Both are time-consuming and neither is readily available for screening purposes.; Purpose: The aim of our study was to evaluate the Montreal Cognitive Assessment (MoCA) test as a screening tool for detection of CD in SLE. Methods. SLE patients fulfilling ACR criteria were administered the ANAM, a computerized test battery which measures various cognitive domains and the MoCA, a one-page, performance-based screening test designed to detect mild cognitive impairment in the elderly. With the ANAM as the gold standard, the performance characteristics of the MoCA were assessed.; Results: In total, 44 patients were evaluated. Of these, 11 (25%) were identified by the ANAM as being impaired in comparison with 13 (29.5%) by the MoCA. The scores were significantly correlated (r = 0.57, p < 0.001). Using the standard cutoff of 26, the sensitivity of MoCA was 83% and specificity 73%.; Conclusion: The MoCA appears to be a promising screening tool for the detection of CD in SLE both for epidemiologic studies and for routine clinical care.;

Bibtex Citation

@article{Adhikari_2011, doi = {10.1177/0961203311405374}, url = {}, year = 2011, month = {jun}, publisher = {{SAGE} Publications}, volume = {20}, number = {11}, pages = {1142--1146}, author = {T. Adhikari and A. Piatti and M. Luggen}, title = {Cognitive dysfunction in {SLE}: development of a screening tool}, journal = {Lupus} }


adult, cognition disorders, complications, diagnosis, etiology, female, humans, lupus erythematosus, systemic, male, middle aged, mild cognitive impairment, neuropsychological tests, psychology, reproducibility of results, statistics & numerical data

Countries of Study


Types of Dementia

Mild Cognitive Impairment (MCI)

Types of Study

Cohort Study

Type of Outcomes


Type of Interventions

Risk Factor Modification

Diagnostic Targets

Cognition testing (inc. task driven tests such as clock drawing)