Viscogliosi, Giovanni, Andreozzi, Paola, Chiriac, Iulia Maria, Cipriani, Elisa, Servello, Adriana, Ettorre, Evaristo, Marigliano, Vincenzo

Background: Metabolic syndrome reaches its highest prevalence in the elderly, and evidence suggests that metabolic syndrome could be an independent risk factor for cognitive impairment. The aims of this study were to detect whether patients with metabolic syndrome have lower cognition and to investigate whether there is a relationship with cognition and single metabolic syndrome […]

Rondanelli, Mariangela, Opizzi, Annalisa, Faliva, Milena, Mozzoni, Marco, Antoniello, Neldo, Cazzola, Roberta, Savarè, Rita, Cerutti, Renata, Grossi, Enzo, Cestaro, Benvenuto

Age-related changes in nutritional status can play an important role in brain functioning. Specific nutrient deficiencies in the elderly may exacerbate pathological processes in the brain. Consequently, the potential of nutritional intervention to prevent or delay cognitive impairment and the development of dementia is an important topic. A randomized, double-blind, placebo-controlled trial has been performed […]

Dockens, Randy, Wang, Jun-Sheng, Castaneda, Lorna, Sverdlov, Oleksandr, Huang, Shu-Pang, Slemmon, Randy, Gu, Huidong, Wong, Oi, Li, Hewei, Berman, Robert M., Smith, Christina, Albright, Charles F., Tong, Gary

Background and Objectives: Avagacestat is an orally active γ-secretase inhibitor that selectively inhibits amyloid β (Aβ) synthesis in cell culture and animal models. The objective of the current study was to assess the pharmacokinetics, pharmacodynamics, safety and tolerability of multiple doses of avagacestat over 28 days in healthy young men and elderly men and women […]

Cazzola, Roberta, Rondanelli, Mariangela, Faliva, Milena, Cestaro, Benvenuto

A randomized, double-blind placebo-controlled clinical trial was carried out to assess the efficacy of a docosahexenoic acid (DHA)-phospholipids, melatonin and tryptophan supplemented diet in improving the erythrocyte oxidative stress, membrane fluidity and membrane-bound enzyme activities of elderly subjects suffering from mild cognitive impairment (MCI). These subjects were randomly assigned to the supplement group (11 subjects, […]

Goodenough, Belinda, Low, Lee-Fay, Casey, Anne-Nicole, Chenoweth, Lynn, Fleming, Richard, Spitzer, Peter, Bell, Jean-Paul, Brodaty, Henry

Background: Humor therapy is a non-pharmacological intervention with potential to improve mood and quality of life for institutionalized older persons, including those with dementia. The primary aims of the Sydney Multisite Intervention of LaughterBosses and ElderClowns (SMILE) are to examine the effects of humor therapy on residents’ mood, quality of life, social engagement, and agitation.; […]

Vannier-Nitenberg, Christiane, Dauphinot, Virginie, Bongue, Bienvenu, Sass, Catherine, Rouch, Isabelle, Beauchet, Olivier, Krolak-Salmon, Pierre, Fantino, Bruno

Background: Only half of those living with Alzheimer’s disease in France are currently diagnosed, and only one patient in three is supported during the early stages of dementia. This study aims to evaluate three cognitive tests for their predictive ability to diagnose mild cognitive impairments and Alzheimer’s disease and related disorders. For people aged 65 […]

Brodaty, Henry, Low, Lee-Fay, Liu, Zhixin, Fletcher, Jennifer, Roast, Joel, Goodenough, Belinda, Chenoweth, Lynn

Objective: To test the hypothesis that individual and institutional-level factors influence the effects of a humor therapy intervention on aged care residents. Methods: Data were from the humor therapy group of the Sydney Multisite Intervention of LaughterBosses and ElderClowns, or SMILE, study, a single-blind cluster randomized controlled trial of humor therapy conducted over 12 weeks; […]