Zare, Maryam, Ebrahimi, Azizeh Afkham, Birashk, Behrouz

Objective: One of the most important challenges in present-day societies is the growing number of patients with Alzheimer’s disease and the related problems afflicted upon the patients, their families, and organizations providing health services. Agitation is one of the behavioral problems present in Alzheimer’s. To overcome these behavioral problems, many pharmaceutical and non-pharmaceutical remedies have […]

van de Ven, Geertje, Draskovic, Irena, Adang, Eddy M. M., Donders, Rogier A. R. T., Post, Aukje, Zuidema, Sytse U., Koopmans, Raymond T. C. M., Vernooij-Dassen, Myrra J. F. J.

Background: The effectiveness and efficiency of nursing-home dementia care are suboptimal: there are high rates of neuropsychiatric symptoms among the residents and work-related stress among the staff. Dementia-care mapping is a person-centred care method that may alleviate both the resident and the staff problems. The main objective of this study is to evaluate the effectiveness […]

De Deyn, Peter Paul, Eriksson, Hans, Svensson, Hanna

Objective: The objective of this study was to assess the safety and tolerability of extended-release quetiapine fumarate (quetiapine XR) compared with quetiapine immediate-release (quetiapine IR) in older patients with Alzheimer’s disease with symptoms of psychosis and/or agitation.; Methods: This was a 6-week, double-blind, double-dummy, randomised study. Of the 109 patients screened, 100 were randomised to […]

Goodenough, Belinda, Low, Lee-Fay, Casey, Anne-Nicole, Chenoweth, Lynn, Fleming, Richard, Spitzer, Peter, Bell, Jean-Paul, Brodaty, Henry

Background: Humor therapy is a non-pharmacological intervention with potential to improve mood and quality of life for institutionalized older persons, including those with dementia. The primary aims of the Sydney Multisite Intervention of LaughterBosses and ElderClowns (SMILE) are to examine the effects of humor therapy on residents’ mood, quality of life, social engagement, and agitation.; […]

Lin, Li-Chan, Yang, Man-Hua, Kao, Chieh-Chun, Wu, Shiao-Chi, Tang, Sai-Hung, Lin, Jaung-Geng

Objectives: To explore the effectiveness of acupressure and Montessori-based activities in decreasing the agitated behaviors of residents with dementia.; Design: A double-blinded, randomized (two treatments and one control; three time periods) cross-over design was used.; Setting: Six special care units for residents with dementia in long-term care facilities in Taiwan were the sites for the […]

Gehrman, Philip R., Connor, Donald J., Martin, Jennifer L., Shochat, Tamar, Corey-Bloom, Jody, Ancoli-Israel, Sonia

Objectives: Patients with Alzheimer dementia often display both agitated behavior and poor sleep. Given that the disease is often associated with low endogenous levels of melatonin, exogenous melatonin administration may lead to improvements in sleep and agitation.; Design: Randomized, placebo-controlled study.; Setting: Nursing homes in San Diego, CA, metropolitan area.; Participants: Subjects were patients with […]

Brodaty, Henry, Low, Lee-Fay, Liu, Zhixin, Fletcher, Jennifer, Roast, Joel, Goodenough, Belinda, Chenoweth, Lynn

Objective: To test the hypothesis that individual and institutional-level factors influence the effects of a humor therapy intervention on aged care residents. Methods: Data were from the humor therapy group of the Sydney Multisite Intervention of LaughterBosses and ElderClowns, or SMILE, study, a single-blind cluster randomized controlled trial of humor therapy conducted over 12 weeks; […]

Aman, Edris, Thomas, David R.

Background: Several studies have shown an improvement in depression, activities of daily living, and agitation in cognitively impaired subjects who undergo a long-term exercise program. These studies have not considered the short-term effects of exercise.; Objectives: The purpose of this study was to investigate the short-term effects of a limited, supervised exercise program on agitation, […]