Del Sindaco, Donatella, Pulignano, Giovanni, Di Lenarda, Andrea, Tarantini, Luigi, Cioffi, Giovanni, Tolone, Stefano, Tinti, Maria Denitza, Monzo, Luca, Barbati, Giulia, Minardi, Giovanni

Background: Cognitive impairment (CI) frequently complicates Heart failure (HF) and is associated with increased mortality and morbidity. Previous studies reported that nurse-lead home-based multidisciplinary program (MP) may not improve the prognosis of this high-risk group. In the present study, we analysed the relative effectiveness of an integrated hospital-based MP in patients with cognitive impairment.; Methods: […]

Cumming, Toby B., Blomstrand, Christian, Bernhardt, Julie, Linden, Thomas

Background: Cognitive impairment is an important but underrecognised consequence of stroke. We investigated whether a subset of items from the NIH Stroke Scale (NIHSS) could yield valid information on cognitive status in a group of stroke patients.; Methods: 149 stroke patients from the Göteborg 70+ Stroke Study were investigated after 18 months. We extracted 4 […]

Heller, Robert B., Dobbs, Bonnie M., Strain, Laurel A.

The effect of cognitively congruent video programming on attentional engagement, as measured by the average look duration and the proportion of the video viewed, was examined among long-term care facility residents with Alzheimer’s disease. Over a 2-week period, 24 residents viewed 4 cognitively congruent videos and 1 control video (ie, a recorded episode of a […]

Santoro, Aurelia, Siviero, Paola, Minicuci, Nadia, Bellavista, Elena, Mishto, Michele, Olivieri, Fabiola, Marchegiani, Francesca, Chiamenti, Andrea Maria, Benussi, Luisa, Ghidoni, Roberta, Nacmias, Benedetta, Bagnoli, Silvia, Ginestroni, Andrea, Scarpino, Osvaldo, Feraco, Emidio, Gianni, Walter, Cruciani, Guido, Paganelli, Roberto, Di Iorio, Angelo, Scognamiglio, Mario, Grimaldi, Luigi Maria Edoardo, Gabelli, Carlo, Sorbi, Sandro, Binetti, Giuliano, Crepaldi, Gaetano, Franceschi, Claudio

Acetylcholinesterase inhibitors (AChEIs) have been used to improve cognitive status and disability in patients with mild to moderate Alzheimer’s disease (AD). However, while the efficacy of AChEIs (i.e. how they act in randomized controlled trials) in this setting is widely accepted, their effectiveness (i.e. how they behave in the real world) remains controversial. To compare […]

Doody, Rachelle S., Raman, Rema, Farlow, Martin, Iwatsubo, Takeshi, Vellas, Bruno, Joffe, Steven, Kieburtz, Karl, He, Feng, Sun, Xiaoying, Thomas, Ronald G., Aisen, Paul S, Siemers, Eric, Sethuraman, Gopalan, Mohs, Richard

Background: Alzheimer’s disease is characterized by the presence of cortical amyloid-beta (Aβ) protein plaques, which result from the sequential action of β-secretase and γ-secretase on amyloid precursor protein. Semagacestat is a small-molecule γ-secretase inhibitor that was developed as a potential treatment for Alzheimer’s disease.; Methods: We conducted a double-blind, placebo-controlled trial in which 1537 patients […]

Camic, P. M., Williams, C. M., Meeten, F.

Ten people with dementia (PWD) and their family carers participated in a Singing Together Group for 10 weeks and measures of mood, quality of life, PWD’s behavioural and psychological problems, activities of daily living and cognitive status were measured at pre, post and 10-week follow-up. Engagement levels were monitored during the sessions and care partners […]

Alagiakrishnan, Kannayiram, Senthilselvan, Ambikaipakan

Objective: Chronic kidney disease is a global public health concern. Glomerular filtration rate (GFR) prediction based on serum creatinine is used to assess renal function in the elderly. The Cockcroft-Gault (CG) formula, based on body surface area (CG/BSA formula), and the Modified Diet and Renal Disease formula (MDRD formula) are commonly used in assessing renal […]