This database contains 114 studies, archived under the term: "baseline"
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Randomized trial of deep brain stimulation for Parkinson disease: thirty-six-month outcomes
Weaver, Frances M.,
Follett, Kenneth A.,
Stern, Matthew,
Luo, Ping,
Harris, Crystal L.,
Hur, Kwan,
Marks, William J., Jr.,
Rothlind, Johannes,
Sagher, Oren,
Moy, Claudia,
Pahwa, Rajesh,
Burchiel, Kim,
Hogarth, Penelope,
Lai, Eugene C.,
Duda, John E.,
Holloway, Kathryn,
Samii, Ali,
Horn, Stacy,
Bronstein, Jeff M.,
Stoner, Gatana,
Starr, Philip A.,
Simpson, Richard,
Baltuch, Gordon,
De Salles, Antonio,
Huang, Grant D.,
Reda, Domenic J.
Objectives: Our objective was to compare long-term outcomes of deep brain stimulation (DBS) of the globus pallidus interna (GPi) and subthalamic nucleus (STN) for patients with Parkinson disease (PD) in a multicenter randomized controlled trial.; Methods: Patients randomly assigned to GPi (n = 89) or STN DBS (n = 70) were followed for 36 months. […]
Efficacy of psychosocial intervention in patients with mild Alzheimer’s disease: the multicentre, rater blinded, randomised Danish Alzheimer Intervention Study (DAISY)
Waldorff, F. B.,
Buss, D. V.,
Eckermann, A.,
Rasmussen, M. L. H.,
Keiding, N.,
Rishøj, S.,
Siersma, V.,
Sørensen, J.,
Sørensen, L. V.,
VOGEL, A.,
WALDEMAR, G.
Objective: To assess the efficacy at 12 months of an early psychosocial counselling and support programme for outpatients with mild Alzheimer’s disease and their primary care givers.; Design: Multicentre, randomised, controlled, rater blinded trial.; Setting: Primary care and memory clinics in five Danish districts.; Participants: 330 outpatients with mild Alzheimer’s disease and their 330 primary […]
Cognitive behavioural therapy (CBT) for anxiety in people with dementia: study protocol for a randomised controlled trial
Spector, Aimee,
Orrell, Martin,
Lattimer, Miles,
Hoe, Juanita,
King, Michael,
Harwood, Kate,
Qazi, Afifa,
Charlesworth, Georgina
Background: Many people with dementia experience anxiety, which can lead to decreased independence, relationship difficulties and increased admittance to care homes. Anxiety is often treated with antipsychotic medication, which has limited efficacy and serious side effects. Cognitive behavioural therapy (CBT) is widely used to treat anxiety in a range of populations, yet no RCTs on […]
Effects of n-3 fatty acids, EPA v. DHA, on depressive symptoms, quality of life, memory and executive function in older adults with mild cognitive impairment: a 6-month randomised controlled trial
Sinn, Natalie,
Milte, Catherine M.,
Street, Steven J.,
Buckley, Jonathan D.,
Coates, Alison M.,
Petkov, John,
Howe, Peter R.C.
Depressive symptoms may increase the risk of progressing from mild cognitive impairment (MCI) to dementia. Consumption of n-3 PUFA may alleviate both cognitive decline and depression. The aim of the present study was to investigate the benefits of supplementing a diet with n-3 PUFA, DHA and EPA, for depressive symptoms, quality of life (QOL) and […]
Amyloid-β(1-15/16) as a marker for γ-secretase inhibition in Alzheimer’s disease
Portelius, Erik,
Zetterberg, Henrik,
Dean, Robert A.,
Marcil, Alexandre,
Bourgeois, Philippe,
Nutu, Magdalena,
Andreasson, Ulf,
Siemers, Eric,
Mawuenyega, Kwasi G.,
Sigurdson, Wendy C.,
May, Patrick C.,
Paul, Steven M.,
Holtzman, David M.,
Blennow, Kaj,
Bateman, Randall J.
Amyloid-β (Aβ) producing enzymes are key targets for disease-modifying Alzheimer’s disease (AD) therapies since Aβ trafficking is at the core of AD pathogenesis. Development of such drugs might benefit from the identification of markers indicating in vivo drug effects in the central nervous system. We have previously shown that Aβ(1-15) is produced by concerted β-and […]
Ageing in general practice (AGP) trial: a cluster randomised trial to examine the effectiveness of peer education on GP diagnostic assessment and management of dementia
Pond, Constance D.,
Brodaty, Henry,
Stocks, Nigel P.,
Gunn, Jane,
Marley, John,
Disler, Peter,
Magin, Parker,
Paterson, Nerida,
Horton, Graeme,
Goode, Susan,
Paine, Bronwen,
Mate, Karen E.
Background: Dementia is increasing in prevalence as the population ages. An earlier rather than later diagnosis allows persons with dementia and their families to plan ahead and access appropriate management. However, most diagnoses are made by general practitioners (GPs) later in the course of the disease and are associated with management that is poorly adherent […]