Thiyagesh, Subha N., Farrow, Tom F. D., Parks, Randolph W., Accosta-Mesa, Hector, Hunter, Michael D., Young, Claire, Wilkinson, lain D., Woodruff, Peter W. R.

Background/Aims: Visuospatial impairments are known to occur in Alzheimer’s disease (AD). We hypothesised that functional magnetic resonance imaging (fMRI) response in task-related brain regions would be impaired in patients with AD during the task and that treatment with acetyl cholinesterase inhibitors would enhance activations in brain regions concerned with this visual perceptual processing. Method: Ten […]

Ehreke, Lena, Luppa, Melanie, König, Hans-Helmut, Villringer, Arno, Riedel-Heller, Steffi G.

Background/Aims: Conversion rates to dementia are known to be high for patients with mild cognitive impairment (MCI), but the diagnosis of MCI is very time-consuming. Since the Clock Drawing Test (CDT) is quick to administer, it will be of interest to compare the predictive validity of the CDT and of an MCI diagnosis for the […]

Carlsson, Cynthia M., Xu, Guofan, Wen, Zhifei, Barnet, Jodi H., Blazel, Hanna M., Chappell, Richard J., Stein, James H., Asthana, Sanjay, Sager, Mark A., Alsop, David C., Rowley, Howard A., Fain, Sean B., Johnson, Sterling C.

Background/aims: Hypercholesterolemia in midlife increases risk for Alzheimer’s disease (AD) and contributes to cerebrovascular dysregulation – an early finding in preclinical AD pathology. Statins improve vascular reactivity, but it is unknown if they increase regional cerebral blood flow (CBF) in individuals at risk for AD.; Methods: In a randomized, controlled, double-blind pilot study, 16 asymptomatic […]

Kolanowski, Ann, Bossen, Ann, Hill, Nikki, Guzman-Velez, Edmarie, Litaker, Mark

Background/aims: Are the noncognitive factors of self-reported mood and personality related to sustained attention in nursing home residents with dementia during an activity intervention?; Methods: Intervention data from a randomized clinical trial were used to address the aim of this project. Subjects were 128 nursing home residents who were assessed for mood, personality, behavioral indicators […]

Han, Hyun Jeong, Kim, Byeong C., Lee, Jun-Young, Ryu, Seung-Ho, Na, Hae-Ri, Yoon, Soo Jin, Park, Hyun Young, Shin, Joon Hyun, Cho, Soo-Jin, Yi, Hyon Ah, Choi, Mun Seong, Heo, Jae-Hyeok, Park, Kyung Won, Kim, Kwang K., Choi, Seong Hye

Background/aims: The apolipoprotein E (APOE) genotype in response to pharmacological treatments in patients with Alzheimer’s disease (AD) remains a matter of controversy. This analysis investigated the effect of the APOE genotype on the clinical response to rivastigmine transdermal patch monotherapy or memantine plus rivastigmine patch in patients with mild to moderate AD.; Methods: Two hundred […]

Guétin, Stéphane, Portet, F., Picot, M. C., Pommié, C., Messaoudi, M., Djabelkir, L., Olsen, A. L., Cano, M. M., Lecourt, E., Touchon, J.

Background/aims: Numerous studies have indicated the value of music therapy in the management of patients with Alzheimer’s disease. A recent pilot study demonstrated the feasibility and usefulness of a new music therapy technique. The aim of this controlled, randomised study was to assess the effects of this new music therapy technique on anxiety and depression […]

Gold, Michael, Alderton, Claire, Zvartau-Hind, Marina, Egginton, Sally, Saunders, Ann M., Irizarry, Michael, Craft, Suzanne, Landreth, Gary, Linnamägi, Ulla, Sawchak, Sharon

Background/aims: A phase II study of the peroxisome proliferator-activated receptor-γ agonist rosiglitazone extended release (RSG XR) in mild-to-moderate Alzheimer’s disease (AD) detected a treatment benefit to cognition in apolipoprotein E(APOE)-ε4-negative subjects. The current phase III study with prospective stratification by APOE genotype was conducted to confirm the efficacy and safety of RSG XR in mild-to-moderate […]

Carcaillon, Laure, Amieva, Hélène, Auriacombe, Sophie, Helmer, Catherine, Dartigues, Jean-François

Background/aims: Episodic memory impairment is known to be the core of Alzheimer’s disease (AD) dementia syndrome and one of the earliest domains to decline. However, episodic memory tests are long and expensive.; Methods: In a sample of the French Three-City Study (n = 1,516), we aimed at validating a subtest of the Mini-Mental State Examination […]