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This database contains 2 studies, archived under the term: "apolipoprotein E genotype"

Effectiveness of a condensed protocol for disclosing APOE genotype and providing risk education for Alzheimer disease

Purpose: Brief, effective models of patient genetic education are needed for common, complex diseases. Using Alzheimer disease as a model, we compared participants’ risk knowledge and recall in extended versus condensed education protocols.; Methods: A four-site randomized clinical trial enrolled 280 first-degree relatives of individuals with Alzheimer disease (mean age = 58 years, 71% female); […]

Plasma concentration of donepezil to the therapeutic response of Alzheimer’s disease in Taiwanese

Donepezil has been approved for the treatment for mild-to-moderate Alzheimer’s disease (AD), but the therapeutic response rate varies from 20 to 60%. A higher oral dosage was suggested to have a better therapeutic response in reported results, but the plasma concentration of donepezil was not examined with respect to the therapeutic outcomes in those studies. […]

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