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This database contains 8 studies, archived under the term: "apathy"

Effectiveness of an individualized functional training program on affective disturbances and functional skills in mild and moderate dementia—A randomized control trial

Objectives: We reported the findings of a randomized controlled trial (RCT) to examine the effects of an individualized functional enhancement program (FEP) on functional skills and mood symptoms in mild and moderate dementia. Subjects & Methods: 74 Chinese older persons with dementia were recruited into a skills training program by occupational therapists (OT). Thirty seven […]

Evaluation of a TEACCH- and music therapy-based psychological intervention in mild to moderate dementia: A controlled trial

Background: A multicomponent psychological intervention designed to alleviate neuropsychiatric symptoms and to improve communication in mild to moderate dementia was evaluated in a controlled trial. Components were (1) TEACCH (Treatment and Education of Autistic and related Communication handicapped Children)-based cognitive-behavioral and environmental interventions adapted for dementia and (2) music therapy. Methods: In a Pre-post design, […]

Physical and cognitive stimulation in Alzheimer Disease. the GAIA Project: a pilot study

Several data suggest that physical activity and cognitive stimulation have a positive effect on the quality of life (QoL) of people with Alzheimer’s disease (AD), slowing the decline due to the disease. A pilot project was undertaken to assess the effect of cognitive stimulation, physical activity, and socialization on patients with AD and their informal […]

Effects of a psychological group intervention on neuropsychiatric symptoms and communication in Alzheimer’s dementia

Background: Outcomes of a multicomponent psychological intervention designed for the treatment of neuropsychiatric symptoms, communicative and emotional deficits in patients with mild to moderate Alzheimer’s dementia were evaluated in a controlled trial. Core components of the program were milieu therapy interventions and music therapy.; Patients and Methods: A total of 49 patients were involved into […]

Effect of six months of treatment with V0191 in patients with suspected prodromal Alzheimer’s disease

New criteria related to prodromal Alzheimer’s disease (AD) have been proposed to overcome the issue of heterogeneity of patients with mild cognitive impairment (MCI) and to better define patients in early stage AD. Only few therapeutic trials, if any, have been reported using this newly defined population. The objective of this study was to assess […]

A randomized, double-blind, placebo-controlled trial of modafinil for the treatment of apathy in individuals with mild-to-moderate Alzheimer’s disease

Objective: This study examined the effects of modafinil on apathetic symptomatology, performance of activities of daily living (ADLs), and caregiver burden in individuals with Alzheimer’s disease (AD).; Method: 23 participants with a diagnosis of mild-to-moderate probable AD according to National Institute of Neurologic and Communicative Disorder and Stroke-Alzheimer’s Disease and Related Disorders criteria were randomized […]

Effect of a non-pharmacological intervention, Voix d’Or(®), on behavior disturbances in Alzheimer disease and associated disorders

An innovative non-pharmacological intervention called Voix d’Or(®) (Golden Voice) was proposed in the Cognitive behavioral unit (CBU) of the Memory center at the Hospices civils in Lyon. Voix d’Or(®) offers eight sound activities disseminated via an audio device based on different approaches sociotherapeutic (music therapy, reminiscence, relaxation, reorientation in reality). The aim of this study […]

The Comprehensive Process Model of Engagement

Background: Engagement refers to the act of being occupied or involved with an external stimulus. In dementia, engagement is the antithesis of apathy. Objective: The Comprehensive Process Model of Engagement was examined, in which environmental, personal, and stimulus characteristics impact the level of engagement. Methods: Participants were 193 residents of 7 Maryland nursing with a […]

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