This database contains 125 studies, archived under the term: "Alzheimer"
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Validation of AclarusDx™, a blood-based transcriptomic signature for the diagnosis of Alzheimer’s disease
Fehlbaum-Beurdeley, Pascale,
Sol, Olivier,
Désiré, Laurent,
Touchon, Jacques,
Dantoine, Thierry,
Vercelletto, Martine,
Gabelle, Audrey,
Jarrige, Anne-Charlotte,
Haddad, Raphaël,
Lemarié, Jean Christophe,
Zhou, Weiyin,
Hampel, Harald,
Einstein, Richard,
Vellas, Bruno
Biomarkers have gained an increased importance in the past years in helping physicians to diagnose Alzheimer’s disease (AD). This study was designed to identify a blood-based, transcriptomic signature that can differentiate AD patients from control subjects. The performance of the signature was then evaluated for robustness in an independent blinded sample population. RNA was extracted […]
Longer duration of hormonal contraceptive use predicts better cognitive outcomes later in life
Background: The cognitive effects of postmenopausal hormone therapy (HT) have been studied extensively, but little is known about the relationship between premenopausal hormone use and cognition. Hormonal contraceptive use vs. nonuse may be a potential factor influencing cognitive processes in midlife. The aim of this study is to explore the effect of modification of hormone […]
Safety of lumbar puncture procedures in patients with Alzheimer’s disease
Changes in cerebrospinal fluid (CSF) biomarkers are representative of biochemical changes in the brain. Collection of CSF by lumbar puncture (LP) is essential for biomarker analysis, which is important for research in neurodegenerative disorders. However, LP for research purposes has been controversial due to a reported high incidence of severe LP headache when using standard […]
CSF biomarker profile and diagnostic value in vascular dementia
Paraskevas, G. P.,
Kapaki, E.,
Papageorgiou, S. G.,
Kalfakis, N.,
Andreadou, E.,
Zalonis, I.,
Vassilopoulos, D.
Background and Purpose: The differential diagnosis between vascular dementia (VD) and Alzheimer’s disease (AD) or mixed dementia (MD) is not always easy in clinical practice. The purpose of the present study was to evaluate the cerebrospinal fluid (CSF) biomarkers tau protein in its total (tau(T)) or hyperphosphorylated at threonin-181(tau(P-181)) form and beta amyloid peptide 1-42 […]
A randomized cross-over study of a traditional Japanese medicine (kampo), yokukansan, in the treatment of the behavioural and psychological symptoms of dementia
Mizukami, Katsuyoshi,
Asada, Takashi,
Kinoshita, Toru,
Tanaka, Katsuaki,
Sonohara, Kazuki,
Nakai, Ryuhei,
Yamaguchi, Kiyoshi,
Hanyu, Haruo,
Kanaya, Kiyoshi,
Takao, Tetsuya,
Okada, Masakatsu,
Kudo, Sumio,
Kotoku, Hayato,
Iwakiri, Masahiko,
Kurita, Hirofumi,
Miyamura, Toshihiro,
Kawasaki, Yosuke,
Omori, Koji,
Shiozaki, Kazumasa,
Odawara, Toshinari,
Suzuki, Tatsuya,
Yamada, Shizuru,
Nakamura, Youichi,
Toba, Kenji
The effectiveness and safety of yokukansan (TJ-54), a traditional Japanese medicine (kampo) for the treatment of the behavioural and psychological symptoms of dementia (BPSD), were evaluated in 106 patients diagnosed as having Alzheimer’s disease (AD) (including mixed-type dementia) or dementia with Lewy bodies. Patients were randomly assigned to group A (TJ-54 treatment in period I […]
Effectiveness of a psychoeducational intervention program in the reduction of caregiver burden in Alzheimer’s disease patients’ caregivers
Martín-Carrasco, Manuel,
Martín, Manuel Franco,
Valero, Carmelo Pelegrín,
Millán, Pedro Roy,
García, Celso Iglesias,
Montalbán, Salvador Ros,
Vázquez, Ana Luisa Gobartt,
Piris, Sonia Pons,
Vilanova, Montserrat Balañá
Objectives: Caregivers of patients with Alzheimer’s disease (AD) experience physical and psychological stress due to the caring experience. This study evaluated the benefits of a Psychoeducational Intervention Program (PIP) on caregiver burden in southern Europe.; Methods: A multicentre, prospective, randomised study was conducted. One hundred and fifteen caregivers of patients with clinical diagnosis of AD […]
Vitamin E paradox in Alzheimer’s disease: it does not prevent loss of cognition and may even be detrimental
Lloret, Ana,
Badía, Mari-Carmen,
Mora, Nancy J.,
Pallardó, Federico V.,
Alonso, Maria-Dolores,
Viña, Jose
There is controversy as to whether vitamin E is beneficial in Alzheimer’s disease (AD). In this study, we tested if vitamin E prevents oxidative stress and loss of cognition in AD. Fifty-seven AD patients were recruited and divided in two groups: placebo or treated with 800 IU of vitamin E per day for six months. […]