Li, Wei, Cheng, Yan-Hong, Yu, Xiao-Gang

Objective: To explore the curative effect and safety of acupuncture for mild cognitive disorders after stroke.; Methods: Randomized controlled trial was adopted and one hundred cases conforming to criteria were divided into a combined acupuncture and medication group (group A) and a medication group (group B), 50 cases in each group. The basic treatment of […]

Iwasaki, Koh, Kosaka, Kenji, Mori, Hideo, Okitsu, Reina, Furukawa, Katsutoshi, Manabe, Yuta, Yoshita, Mitsuhiro, Kanamori, Aya, Ito, Nobuo, Wada, Kenji, Kitayama, Michio, Horiguchi, Jun, Yamaguchi, Shuhei, Takayama, Shin, Fukuhara, Ryuji, Ouma, Shinji, Nakano, Seigo, Hashimoto, Mamoru, Kinoshita, Toru

Background: This multicentre open-label trial examined the efficacy and safety of the traditional Japanese medicine, or Kampo medicine, yokukansan (YKS), for behavioural and psychological symptoms of dementia (BPSD) in patients with dementia with Lewy bodies.; Methods: Sixty-three dementia with Lewy bodies patients with probable BPSD (M:W, 30:33; mean age, 78.2±5.8 years) were enrolled and treated […]

Mizukami, Katsuyoshi, Asada, Takashi, Kinoshita, Toru, Tanaka, Katsuaki, Sonohara, Kazuki, Nakai, Ryuhei, Yamaguchi, Kiyoshi, Hanyu, Haruo, Kanaya, Kiyoshi, Takao, Tetsuya, Okada, Masakatsu, Kudo, Sumio, Kotoku, Hayato, Iwakiri, Masahiko, Kurita, Hirofumi, Miyamura, Toshihiro, Kawasaki, Yosuke, Omori, Koji, Shiozaki, Kazumasa, Odawara, Toshinari, Suzuki, Tatsuya, Yamada, Shizuru, Nakamura, Youichi, Toba, Kenji

The effectiveness and safety of yokukansan (TJ-54), a traditional Japanese medicine (kampo) for the treatment of the behavioural and psychological symptoms of dementia (BPSD), were evaluated in 106 patients diagnosed as having Alzheimer’s disease (AD) (including mixed-type dementia) or dementia with Lewy bodies. Patients were randomly assigned to group A (TJ-54 treatment in period I […]

Banerjee, Sube, Hellier, Jennifer, Dewey, Michael, Romeo, Renee, Ballard, Clive, Baldwin, Robert, Bentham, Peter, Fox, Chris, Holmes, Clive, Katona, Cornelius, Knapp, Martin, Lawton, Claire, Lindesay, James, Livingston, Gill, McCrae, Niall, Moniz-Cook, Esme, Murray, Joanna, Nurock, Shirley, Orrell, Martin, O'Brien, John, Poppe, Michaela, Thomas, Alan, Walwyn, Rebecca, Wilson, Kenneth, Burns, Alistair

Background: Depression is common in dementia but the evidence base for appropriate drug treatment is sparse and equivocal. We aimed to assess efficacy and safety of two of the most commonly prescribed drugs, sertraline and mirtazapine, compared with placebo.; Methods: We undertook the parallel-group, double-blind, placebo-controlled, Health Technology Assessment Study of the Use of Antidepressants […]