This database contains 7 studies, archived under the term: "addition"
Anticholinergic drug use and risk for dementia: Target for dementia prevention
Jessen, Frank,
Kaduszkiewicz, Hanna,
Daerr, Moritz,
Bickel, Horst,
Pentzek, Michael,
Riedel-Heller, Steffi,
Wagner, Michael,
Weyerer, Siegfried,
Wiese, Birgitt,
van den Bussche, Hendrik,
Broich, Karl,
Maier, Wolfgang
An increasing number of longitudinal cohort studies have identified a risk increase for dementia by the chronic use of drugs with anticholinergic properties. The respective data from the German Study on Aging, Cognition and Dementia in Primary Care Patients (AgeCoDe) also showing risk increase (hazard ratio = 2.081) are reported here. The mechanisms by which […]
Two galantamine titration regimens in patients switched from donepezil
Engedal, K.,
Davis, B.,
Richarz, U.,
Han, J.,
Schäuble, B.,
Andreasen, N.
Objectives: In addition to inhibiting acetylcholinesterase, galantamine has allosteric-modulating activity at nicotinic receptors. This may make galantamine an attractive option for patients starting treatment for Alzheimer’s disease (AD), but also for those who have not benefited from their current therapy. This study explored outcomes in subjects with AD transitioning from donepezil because of insufficient tolerability […]
Mobility training after hip fracture: a randomised controlled trial
Moseley, Anne M.,
Sherrington, Catherine,
Lord, Stephen R.,
Barraclough, Elizabeth,
St George, Rebecca J.,
Cameron, Ian D.
Objective: to compare the effects of two different exercise programmes after hip fracture.; Design: assessor-blinded randomised controlled trial.; Setting: hospital rehabilitation units, with continued intervention at home.; Subjects: 160 people with surgical fixation for hip fracture transferred to inpatient rehabilitation.; Method: in addition to other rehabilitation strategies, the intervention group received a higher dose (60 […]
V-TIME: a treadmill training program augmented by virtual reality to decrease fall risk in older adults: study design of a randomized controlled trial
Mirelman, Anat,
Rochester, Lynn,
Reelick, Miriam,
Nieuwhof, Freek,
Pelosin, Elisa,
Abbruzzese, Giovanni,
Dockx, Kim,
Nieuwboer, Alice,
Hausdorff, Jeffrey M.
Background: Recent work has demonstrated that fall risk can be attributed to cognitive as well as motor deficits. Indeed, everyday walking in complex environments utilizes executive function, dual tasking, planning and scanning, all while walking forward. Pilot studies suggest that a multi-modal intervention that combines treadmill training to target motor function and a virtual reality […]
Comparing the efficacy and safety of Crocus sativus L. With memantine in patients with moderate to severe Alzheimer’s disease: A double‐blind randomized clinical trial
Farokhnia, Mehdi,
Shafiee Sabet, Mehdi,
Iranpour, Negar,
Gougol, Amirhossein,
Yekehtaz, Habibeh,
Alimardani, Roozbeh,
Farsad, Farzaneh,
Kamalipour, Maryam,
Akhondzadeh, Shahin
Objectives Limited pharmacological options are available for the management of Alzheimer’s disease (AD) in severe stages. Cognitive‐enhancing properties of saffron, the dried stigma of Crocus sativus L., have been evidenced in different studies. We aimed to compare the efficacy and safety of saffron extract versus memantine in reducing cognitive deterioration of patients with moderate to […]
The impact of stimulus attributes on engagement of nursing home residents with dementia
We examined the influence of stimulus attributes on the engagement of 69 nursing home residents with dementia. Specifically,we looked at work-related stimuli versus manipulative block stimuli, and whether the color, size, and material of a stimulus affect the duration and quality of engagement. Engagement was assessed using the Observational Measurement of Engagement (OME). Results revealed […]