This database contains 6 studies, archived under the term: "ADAS-cog scores"
Cognitive intervention response is related to habitual physical activity in older adults
Background and Aims: This study analysed the associations between physical activity and the effects of cognitive training on perceived cognitive functioning and life satisfaction in older adults.; Methods: A sample of 114 intervention group participants (65-89 yrs) received weekly group sessions of cognitive stimulation for two months. This sample was stratified into groups according to […]
Donepezil treatment of patients with MCI: a 48-week randomized, placebo-controlled trial
Background: Treatment of mild cognitive impairment (MCI) with cholinesterase inhibitors may improve symptoms.; Methods: In this multicenter, randomized, placebo-controlled trial, subjects with MCI entered a 3-week placebo run-in period followed by 48 weeks of double-blind donepezil (5 mg/day for 6 weeks, then 10 mg/day for 42 weeks) or placebo treatment. Primary efficacy variables included change […]
A phase 3 trial of semagacestat for treatment of Alzheimer’s disease
Background: Alzheimer’s disease is characterized by the presence of cortical amyloid-beta (Aβ) protein plaques, which result from the sequential action of β-secretase and γ-secretase on amyloid precursor protein. Semagacestat is a small-molecule γ-secretase inhibitor that was developed as a potential treatment for Alzheimer’s disease.; Methods: We conducted a double-blind, placebo-controlled trial in which 1537 patients […]