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Prazosin for the treatment of behavioral symptoms in patients with Alzheimer disease with agitation and aggression
Wang, Lucy Y.,
Shofer, Jane B.,
Rohde, Kirsten,
Hart, Kim L.,
Hoff, David J.,
McFall, Yun H.,
Raskind, Murray A.,
Peskind, Elaine R.
Objectives: Agitation/aggression in Alzheimer disease (AD) is a major cause of patient distress, caregiver burden, and institutionalization. Enhanced behavioral responsiveness to central nervous system norepinephrine (NE) release may contribute to the pathophysiology of agitation/aggression in AD. Prazosin, a nonsedating generic medication used for hypertension and benign prostatic hypertrophy, antagonizes NE effects at brain postsynaptic alpha-1 […]
Group reminiscence intervention in Taiwanese elders with dementia
The purpose of this study was to evaluate the effect of structured group reminiscence therapy on behavior competence and physical functioning and to compare effectiveness of the intervention by stage of dementia in Taiwanese elders residing in institutional settings. A longitudinal experimental design was used. Seventy-seven Taiwanese elderly participants completed the study; 38 in the […]
Video decision support tool for advance care planning in dementia: randomised controlled trial
Volandes, Angelo E.,
Paasche-Orlow, Michael K.,
Barry, Michael J.,
Gillick, Muriel R.,
Minaker, Kenneth L.,
Chang, Yuchiao,
Cook, E. Francis,
Abbo, Elmer D.,
El-Jawahri, Areej,
Mitchell, Susan L.
Objective: To evaluate the effect of a video decision support tool on the preferences for future medical care in older people if they develop advanced dementia, and the stability of those preferences after six weeks.; Design: Randomised controlled trial conducted between 1 September 2007 and 30 May 2008. Setting Four primary care clinics (two geriatric […]
Using video images to improve the accuracy of surrogate decision-making: a randomized controlled trial
Introduction: When patients are unable to make important end-of-life decisions, doctors ask surrogate decision makers to provide insight into patients’ preferences. Unfortunately, multiple studies have shown that surrogates’ knowledge of patient preferences is poor. We hypothesized that a video decision tool would improve concordance between patients and their surrogates for end-of-life preferences.; Objective: To compare […]
Improvement of spontaneous speech in early stage Alzheimer’s with rivastigmine
Visch Brink, E. G.,
Van Rhee Temme, W.,
Rietveld, T.,
Krulder, J. W. M.,
Van Harskamp, F.,
Van der Cammen, T. J. M.
Objectives: Placebo-controlled trials have shown that rivastigmine can delay cognitive deterioration in patients with mild to moderate Alzheimer’s disease (AD). Benefits on cognitive functioning, as measured with the ADAS-Cog, occur on a daily dose of 6-12 mg when used for at least 6 months. The effect of rivastigmine on the adequacy of spontaneous speech is […]
Therapeutic conversation to improve mood in nursing home residents with Alzheimer’s disease
Few studies have tested strategies to address the mental health needs of individuals with Alzheimer’s disease (AD). To test a newly developed, empirically based modified counseling approach, 30 nursing home residents with AD were randomly assigned to a modified counseling (Therapeutic Conversation) treatment group or usual care control group. Mini-Mental State Examination mean scores were […]