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This database contains 1433 studies, archived under the term: ""

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Underestimation of cognitive impairment by Mini-Mental State Examination versus the Montreal Cognitive Assessment in patients with transient ischemic attack and stroke: a population-based study
Background and Purpose: The Mini-Mental State Examination (MMSE) is insensitive to mild cognitive impairment and executive function. The more recently developed Montreal Cognitive Assessment (MoCA), an alternative, brief 30-point global cognitive screen, might pick up more cognitive abnormalities in patients with cerebrovascular disease.; Methods: In a population-based study (Oxford Vascular Study) of transient ischemic attack […]

Effects of a restraint minimization program on staff knowledge, attitudes, and practice: a cluster randomized trial
Objectives: To evaluate the effects of a restraint minimization education program on staff knowledge and attitudes and use of physical restraints.; Design: Cluster-randomized controlled trial with nursing units as the basis for randomization.; Setting: Forty group dwelling units for people with dementia.; Participants: At baseline, there were 184 staff and 191 residents in the intervention […]

A chronic grief intervention for dementia family caregivers in long-term care
Dementia caregivers do not relinquish their role after placing family members in long-term care and they experience increased chronic grief. The Chronic Grief Management Intervention (CGMI) is a12-week group-based program that uses guided discussion to deliver knowledge of Alzheimer’s or a related dementia and teach skills in communication, conflict resolution, and chronic grief management in […]

Prediction of manifest Huntington’s disease with clinical and imaging measures: a prospective observational study
Background: Although the association between cytosine-adenine-guanine (CAG) repeat length and age at onset of Huntington’s disease is well known, improved prediction of onset would be advantageous for clinical trial design and prognostic counselling. We compared various measures for tracking progression and predicting conversion to manifest Huntington’s disease.; Methods: In this prospective observational study, we assessed […]

Peaceful Mind: an open trial of cognitive-behavioral therapy for anxiety in persons with dementia
Background: Anxiety has a high prevalence among individuals with dementia, and it has a significant negative impact on their functioning; yet intervention studies are lacking. We developed Peaceful Mind, a cognitive-behavioral intervention for persons with dementia. In this paper, we describe the intervention and results of an open trial evaluating the feasibility and utility of […]

Development and application of medication appropriateness indicators for persons with advanced dementia: A feasibility study
Background: No studies have been conducted in the UK context to date that categorise medications in terms of appropriateness for patients with advanced dementia, or that examine medication use in these vulnerable patients. Objectives: The objectives of this study were to categorise the appropriateness of a comprehensive list of medications and medication classes for use […]

Effect of treatment gaps in elderly patients with dementia treated with cholinesterase inhibitors
Objective: To determine the effect of treatment gaps on the risk of institutionalization or death among community-dwelling elderly patients treated with cholinesterase inhibitors (ChIs).; Methods: A survival analysis was conducted among a cohort of community-dwelling elderly patients (age 66+) newly treated with ChIs identified in the Quebec drug claims databases (Régie de l’Assurance Maladie du […]

Isolated theory of mind deficits and risk for frontotemporal dementia: A longitudinal pilot study
Objective: Recent data suggest that theory of mind (ToM) deficits represent an early symptom of the behavioural variant of frontotemporal dementia (bvFTD). However, longitudinal data on the natural history of subjects presenting with isolated ToM deficits are lacking. The aim of the study was to verify if isolated ToM deficits represent an at-risk state for […]

Validation of the Hungarian version of Alzheimer’s Disease Assessment Scale-Cognitive Subscale (ADAS-Cog) in patients with mild cognitive impairment
Introduction: Early recognition of mild cognitive impairment (MCI) has increasing clinical relevance in the treatment process of dementia, since it is considered as prodromal period. A great variety of instruments have been developed for measuring cognitive performance of the demented patients. The cognitive subscale of the Alzheimer’s Disease Assessment Scale (ADAS-Cog) is one of the […]

Fetal striatal grafting slows motor and cognitive decline of Huntington’s disease
Objective: To assess the clinical effect of caudate-putaminal transplantation of fetal striatal tissue in Huntington’s disease (HD).; Methods: We carried out a follow-up study on 10 HD transplanted patients and 16 HD not-transplanted patients. All patients were evaluated with the Unified HD Rating Scale (UHDRS) whose change in motor, cognitive, behavioural and functional capacity total […]

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