Boada, Mercè, Arranz, Francisco Javier

Background and Aims: Poor adherence to anti-dementia drugs is common among patients with Alzheimer’s disease. This study evaluated whether caregivers were more satisfied with, and patients more adherent to, transdermal rivastigmine than oral rivastigmine.; Methods: Neurologists, psychiatrists and geriatricians collected sociodemographic and clinical data from 1,078 patients and administered the Treatment Satisfaction with Medicines (SATMED-Q) […]

Alva, Gustavo, Grossberg, George T., Schmitt, Frederick A., Meng, Xiangyi, Olin, Jason T.

Objective: In Alzheimer’s disease (AD), rivastigmine has demonstrated statistically significant efficacy versus placebo on cognition and activities of daily living (ADL). The aim of this retrospective analysis was to further evaluate the treatment effects of rivastigmine on individual ADL items.; Methods: This exploratory analysis focused on the Alzheimer’s Disease Cooperative Study Activities of Daily Living […]

Schmidt, Reinhold, Alf, Claude, Bancher, Christian, Benke, Thomas, Berek, Klaus, Dal-Bianco, Peter, Führwürth, Gerhard, Imarhiagbe, Douglas, Jagsch, Christian, Lechner, Anita, Rainer, Michael, Reisecker, Franz, Rotaru, Juliana, Uranüs, Margarete, Walter, Andreas, Winkler, Andreas, Wuschitz, Albert

We performed a 6-month open-label study on the use of the transdermal rivastigmine patch in clinical routine in 103 patients with Alzheimer’s disease from 25 outpatient services in Austria. After baseline, safety and tolerability of the 10 cm2–rivastigmine patch was assessed at week 4, 12 and 24 in all patients. A Mini Mental State Examination […]

Sadowsky, Carl H., Dengiz, Alan, Olin, Jason T., Koumaras, Barbara, Meng, Xiangyi, Brannan, Stephen

Objective: Evaluate safety and tolerability of switching from donepezil to rivastigmine transdermal patch in patients with mild to moderate Alzheimer’s disease.; Methods: Prospective, parallel-group, open-label study to evaluate immediate or delayed switch from 5-10 mg/day donepezil to 4.6 mg/24 h rivastigmine following a 4-week treatment period.; Results: Rates of discontinuation due to any reason or […]

Wouters, C. J., Dautzenberg, L., Thissen, A., Dautzenberg, P. L. J.

Objectives: Since January 2008 in The Netherlands, two cholinesterase inhibitors, oral galantamine and rivastigmine transdermal patch, are registered as a one-day symptomatic treatment for Alzheimer’s disease. As no head to head study was performed yet, the objective of this study was to describe the daily practice of oral galantamine and rivastigmine transdermal patch in a […]

Sandvik, R. K., Selbaek, G., Seifert, R., Aarsland, D., Ballard, C., Corbett, A., Husebo, B. S.

Background: Pain is frequent and distressing in people with dementia, but no randomized controlled trials have evaluated the effect of analgesic treatment on pain intensity as a key outcome. Methods: Three hundred fifty‐two people with dementia and significant agitation from 60 nursing home units were included in this study. These units, representing 18 nursing homes […]

Sadowsky, C. H., Farlow, M. R., Meng, X., Olin, J. T.

Objectives: To compare the safety and tolerability of switching patients with mild-to-moderate Alzheimer’s disease from donepezil to either rivastigmine capsule or transdermal patch.; Methods: Three studies investigated the switch from donepezil to rivastigmine; study US13 was a 26-week, single-arm, immediate-switch study; US18 was a 26-week, sequential cohort study (both studies evaluated rivastigmine capsules 3-12 mg/day); […]

Husebo, B. S., Ballard, C., Sandvik, R., Nilsen, O. B., Aarsland, D.

Objective: To determine whether a systematic approach to the treatment of pain can reduce agitation in people with moderate to severe dementia living in nursing homes.; Design: Cluster randomised controlled trial.; Setting: 60 clusters (single independent nursing home units) in 18 nursing homes within five municipalities of western Norway.; Participants: 352 residents with moderate to […]

Husebo, B. S., Ballard, C., Fritze, F., Sandvik, R. K., Aarsland, D.

Background: Depression is common in nursing home (NH) patients with dementia, and often clustered with anxiety and other mood symptoms. An association between pain and depressive symptoms has been reported, but the impact of pain management on depression and other mood symptoms has not been investigated. Objective: Secondary analyses of a cluster randomized clinical trial […]