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This database contains 13 studies, archived under the term: "symptoms"

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Changes in cognitive functions of patients with dementia of the Alzheimer type following long-term administration of donepezil hydrochloride: Relating to changes attributable to differences in apolipoprotein E phenotype
Aim: We conducted a study of changes in cognitive functions by long-term monitoring of dementia of Alzheimer type (DAT) patients to investigate the relationship between the progression of DAT symptoms and the presence of apolipoprotein (ApoE)4. Methods: The subjects consisted of 40 DAT patients who had been treated with donepezil for 3 years or more. […]

Effectiveness of an individualized functional training program on affective disturbances and functional skills in mild and moderate dementia—A randomized control trial
Objectives: We reported the findings of a randomized controlled trial (RCT) to examine the effects of an individualized functional enhancement program (FEP) on functional skills and mood symptoms in mild and moderate dementia. Subjects & Methods: 74 Chinese older persons with dementia were recruited into a skills training program by occupational therapists (OT). Thirty seven […]

Evaluation of a TEACCH- and music therapy-based psychological intervention in mild to moderate dementia: A controlled trial
Background: A multicomponent psychological intervention designed to alleviate neuropsychiatric symptoms and to improve communication in mild to moderate dementia was evaluated in a controlled trial. Components were (1) TEACCH (Treatment and Education of Autistic and related Communication handicapped Children)-based cognitive-behavioral and environmental interventions adapted for dementia and (2) music therapy. Methods: In a Pre-post design, […]

The moderating effect of nutritional status on depressive symptoms in veteran elders with dementia: A spaced retrieval combined with Montessori‐based activities
Aim: To examine the long-term effects of fixed/individualized spaced retrieval combined with Montessori-based activities on nutritional status and body mass index and nutritional improvement’s moderating effect on depressive symptoms for people with dementia during a specific follow-up period. Background: The decrease in food intake, often combined with poor nutrition, may induce depressive symptoms in people […]

A randomized controlled trial for an individualized positive psychosocial intervention for the affective and behavioral symptoms of dementia in nursing home residents
Objectives: This randomized controlled study tested the effectiveness of individualized activities, led by certified nursing assistants (CNAs), to increase positive and reduce negative affect and behavior among nursing home residents with dementia. Method: Nursing home residents with mild to advanced dementia (N = 180) were randomly assigned to usual care (UC, n = 93) or […]

Prevalence of psychotropic medication use among German and Austrian nursing home residents: a comparison of 3 cohorts
Background: Despite increasing knowledge about the limited effectiveness and severe adverse effects, the prescription rate of psychotropic medications in frail elderly persons remains high. Prescriptions are mainly made to control behavioral and psychological symptoms of dementia, although factors associated with prescriptions are rarely reported. However, such information is a prerequisite to develop intervention programs aiming […]

Prediction of manifest Huntington’s disease with clinical and imaging measures: a prospective observational study
Background: Although the association between cytosine-adenine-guanine (CAG) repeat length and age at onset of Huntington’s disease is well known, improved prediction of onset would be advantageous for clinical trial design and prognostic counselling. We compared various measures for tracking progression and predicting conversion to manifest Huntington’s disease.; Methods: In this prospective observational study, we assessed […]

Development and application of medication appropriateness indicators for persons with advanced dementia: A feasibility study
Background: No studies have been conducted in the UK context to date that categorise medications in terms of appropriateness for patients with advanced dementia, or that examine medication use in these vulnerable patients. Objectives: The objectives of this study were to categorise the appropriateness of a comprehensive list of medications and medication classes for use […]

The effect of exercise on behavioural and psychological symptoms of dementia: The EVIDEM-E randomised controlled clinical trial
Objective: The objective of this study is to evaluate the effectiveness of a simple dyadic (person with dementia and their main carer) exercise regimen as a therapy for the behavioural and psychological symptoms of dementia. Method: A two arm, pragmatic, randomised, controlled, single‐blind, parallel‐group trial of a dyadic exercise regimen (individually tailored walking regimen designed […]

Memantine improves goal attainment and reduces caregiver burden in Parkinson’s disease with dementia
Objective: Memantine, an uncompetitive antagonist of N‐methyl‐D‐aspartate receptors, may have a role in managing symptoms associated with dementia in Parkinson’s disease (PDD), although its role in improving patient‐reported outcomes (PROs) has not been extensively investigated. PROs may be more sensitive than standard psychometric measures for detecting change in complex conditions such as PDD. The aim […]

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