Skillbäck, Tobias, Rosén, Christoffer, Asztely, Fredrik, Mattsson, Niklas, Blennow, Kaj, Zetterberg, Henrik

Importance: Identifying a clinical distinction between the invariably lethal prion disease Creutzfeldt-Jakob disease (CJD) and nonprion rapidly progressive dementias is important and sometimes difficult; thus, reliable tools for diagnosis are in great demand.; Objective: To test the diagnostic performance of dementia cerebrospinal fluid (CSF) biomarkers total tau (T-tau), phosphorylated tau (P-tau), and the T-tau to […]

Ryynänen, O.-P., Nousiainen, P., Soini, E.J.O., Tuominen, S.

Aim: The goal of the present work was to measure the efficacy of a multicomponent programme designed to provide tailored support for the caregivers of disabled persons.; Subjects: A total of 135 caregivers-care receiver dyads were randomly divided into an intervention group (n = 66) and a control group (n = 69). One-third of the […]

Obisesan, Thomas O, Gillum, RF

Background: Prior research suggests an interaction between social networks and Alzheimer’s disease pathology and cognitive function, all predictors of survival in the elderly. We test the hypotheses that both social integration and cognitive function are independently associated with subsequent mortality and there is an interaction between social integration and cognitive function as related to mortality […]

Lazzeroni, Laura C., Halbauer, Joshua D., Ashford, J. Wesson, Noda, Art, Hernandez, Beatriz, Azor, Virgina, Hozack, Nikki, Hasson, Noelle, Henderson, Victor W., Yesavage, Jerome A., Tinklenberg, Jared R.

Alzheimer’s disease (AD) shortens life-expectancy, but the effects of pharmacological treatments for this disorder on mortality have not been studied. We compared two commonly prescribed medications, donepezil and memantine, with respect to the length of survival of veterans presumed to have AD. The Computerized Medical Records System at the Veterans Affairs Palo Alto Health Care […]

Geschwind, M. D., Kuo, A. L., Wong, K. S., Haman, A., Devereux, G., Raudabaugh, B. J., Johnson, D. Y., Torres-Chae, C. C., Finley, R., Garcia, P., Thai, J. N., Cheng, H. Q., Neuhaus, J. M., Forner, S. A., Duncan, J. L., Possin, K. L., DeArmond, S. J., Prusiner, S. B., Miller, B. L.

Objective: To determine whether oral quinacrine increases survival in sporadic Creutzfeldt-Jakob disease (sCJD).; Methods: This NIH/National Institute on Aging-funded, double-blinded, placebo-controlled, stratified randomization treatment trial was conducted at the University of California, San Francisco from February 2005 through May 2009 (ClinicalTrials.gov, NCT00183092). Subjects were randomized (50:50) to quinacrine (300 mg daily) or placebo with inpatient […]