Rodríguez-Mansilla, Juan, González-López-Arza, María Victoria, Varela-Donoso, Enrique, Montanero-Fernández, Jesús, Jiménez-Palomares, María, Garrido-Ardila, Elisa Maria

Objective: To assess the impact of massage versus ear acupuncture on behavior and participation in occupational therapy of dementia patients.; Methods: We performed a controlled, randomized longitudinal trial approved by the Bioethics Commission of the University of Extremadura. One hundred twenty elderly subjects with dementia institutionalized in residential homes in Extremadura (Spain) received treatment based […]

Petiau, Christophe, Onen, Hakki, Delgado, Antonio, Touchon, Jacques

Presents a study which aims to explore sleep related outcomes in patients with mild moderate Alzheimer’s disease (AD) initiating acetylcholinesterase inhibitor therapy. This study is a prospective, observational, longitudinal, multicentre survey evaluating sleep quality in AD patients initiating acetylcholinesterase inhibitor (AChEI) treatment. Data for this study were collected at AChEI initiation and after 3 to […]

Ooms, Sharon, Overeem, Sebastiaan, Besse, Kees, Rikkert, Marcel Olde, Verbeek, Marcel, Claassen, Jurgen A. H. R.

Importance: Increasing evidence suggests a relationship between poor sleep and the risk of developing Alzheimer disease. A previous study found an effect of sleep on β-amyloid (Aβ), which is a key protein in Alzheimer disease pathology.; Objective: To determine the effect of 1 night of total sleep deprivation on cerebrospinal fluid Aβ42 protein levels in […]

Lundin, Anders, Dietrichs, Espen, Haghighi, Sara, Göller, Marie-Louise, Heiberg, Arvid, Loutfi, Ghada, Widner, Håkan, Wiktorin, Klas, Wiklund, Leif, Svenningsson, Anders, Sonesson, Clas, Waters, Nicholas, Waters, Susanna, Tedroff, Joakim

Objectives: To evaluate the efficacy and safety of the dopaminergic stabilizer pridopidine (ACR16) in patients with Huntington’s disease (HD).; Methods: In a randomized, double-blind, placebo-controlled, 4-week trial, patients with HD received pridopidine (50 mg/d, n = 28) or placebo (n = 30). The primary outcome measure was the change from baseline in weighted cognitive score, […]

Husebo, B. S., Ballard, C., Fritze, F., Sandvik, R. K., Aarsland, D.

Background: Depression is common in nursing home (NH) patients with dementia, and often clustered with anxiety and other mood symptoms. An association between pain and depressive symptoms has been reported, but the impact of pain management on depression and other mood symptoms has not been investigated. Objective: Secondary analyses of a cluster randomized clinical trial […]

Hirano, Akemi, Suzuki, Yusuke, Kuzuya, Masafumi, Onishi, Joji, Ban, Nobutaro, Umegaki, Hiroyuki

With an aim to improve quality of life in caregivers of dementia patients, we examined the effect of regular exercise on caregivers’ sense of burden and their physical symptoms. Participants were 31 elderly caregivers living with older patients diagnosed with Alzheimer’s-type dementia. They were randomly assigned to either the intervention group, who were prescribed regular […]

Camargos, Einstein F., Louzada, Luciana L., Quintas, Juliana L., Naves, Janeth O.S., Louzada, Fernando M., Nóbrega, Otávio T.

Objectives: There are no randomized clinical trials regarding efficacy of trazodone in the treatment of sleep disturbances (SD) in patients with Alzheimer disease (AD). We tested the efficacy and safety of trazodone to treat SD in patients with AD. Design: We conducted a double-blind, randomized and controlled trial during periods of 7–9 days at baseline […]