Simoncini, M., Gatti, A., Quirico, P. E., Balla, S., Capellero, B., Obialero, R., D'Agostino, S., Sandri, N., Pernigotti, L. M.

BACKGROUND: Sleep disorders are very common in elderly institutionalized people with dementia and acupressure recently has been associated with conventional medicine in their treatment. AIMS: Exploring the effectiveness of acupressure for the treatment of insomnia and other sleep disturbances and we want to show that the acupressure treatment is feasible also in elderly resident patients. […]

McCurry, Susan M., Pike, Kenneth C., Vitiello, Michael V., Logsdon, Rebecca G., Larson, Eric B., Teri, Linda

Objectives: To test the effects of walking, light exposure, and a combination intervention (walking, light, and sleep education) on the sleep of persons with Alzheimer’s disease (AD).; Design: Randomized, controlled trial with blinded assessors.; Setting: Independent community living.; Participants: One hundred thirty-two people with AD and their in-home caregivers.; Interventions: Participants were randomly assigned to […]

Larsson, Victoria, Aarsland, Dag, Ballard, Clive, Minthon, Lennart, Londos, Elisabet

Objective: Two common and characteristic sleep disturbances have been described in dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD); excessive daytime sleepiness and REM sleep behaviour disorder (RBD). This study is an analysis of a secondary outcome measure of a larger study already reported, aimed to determine whether memantine has an effect on […]

Doody, Rachelle S., Ferris, Steven, Salloway, Stephen, Yijun, Sun, Goldman, Robert, Yikang, Xu, Gao, Jeff, Murthy, Anita K.

Following a 48-week, double-blind, randomized, placebo-controlled trial of donepezil in 821 patients with amnestic mild cognitive impairment (aMCI), safety and tolerability of donepezil (10 mg) were further evaluated in a 28-week extension study. Of 499 participants who completed the double-blind phase, 145 enrolled in the open-label study. Adverse events (AEs) were recorded throughout. Overall, 57.4% […]