Jackson, Graham S., Burk-Rafel, Jesse, Edgeworth, Julie Ann, Sicilia, Anita, Abdilahi, Sabah, Korteweg, Justine, Mackey, Jonathan, Thomas, Claire, Wang, Guosu, Schott, Jonathan M., Mummery, Catherine, Chinnery, Patrick F., Mead, Simon, Collinge, John

Importance: Our study indicates a prototype blood-based variant Creutzfeldt-Jakob disease (vCJD) assay has sufficient sensitivity and specificity to justify a large study comparing vCJD prevalence in the United Kingdom with a bovine spongiform encephalopathy-unexposed population. In a clinical diagnostic capacity, the assay’s likelihood ratios dramatically change an individual’s pretest disease odds to posttest probabilities and […]

Hosking, Diane E., Nettelbeck, Ted, Wilson, Carlene, Danthiir, Vanessa

Dietary intake is a modifiable exposure that may have an impact on cognitive outcomes in older age. The long-term aetiology of cognitive decline and dementia, however, suggests that the relevance of dietary intake extends across the lifetime. In the present study, we tested whether retrospective dietary patterns from the life periods of childhood, early adulthood, […]

Hebert, Paul L., McBean, Alexander Marshall, O'Connor, Heidi, Frank, Barbara, Good, Charles, Maciejewski, Matthew L.

Background: Centrally active (CA) angiotensin-converting enzyme inhibitors (ACEIs) are able to cross the blood–brain barrier. Small observational studies and mouse models suggest that use of CA versus non-CA ACEIs is associated with a reduced incidence of Alzheimer’s disease and related dementias (ADRD).; Objective: The aim of this research was to assess the effect of CA […]

Grimaldi, Luigi Maria, Zappalà, Giuseppe, Iemolo, Francesco, Castellano, Anna, Ruggieri, Stefano, Bruno, Giuseppe, Paolillo, Andrea

Despite the fact that multiple sclerosis (MS) and Alzheimer’s disease (AD) share common neuroimmunological features, interferon beta 1a (IFNβ1a), the well-established treatment for the prevention of disease progression and cognitive decline in MS patients, has never been used in AD. We evaluated the safety and efficacy of IFNβ1a in subjects affected by mild-to-moderate AD in […]

Gozalo, Pedro, Prakash, Shivaani, Qato, Danya M., Sloane, Philip D., Mor, Vincent

Objectives: To evaluate the effectiveness of the Bathing Without a Battle intervention in reducing physical and verbal aggressive behaviors for nursing home residents with dementia.; Design: A randomized crossover diffusion study, with one group receiving the intervention after one round of baseline observations and a delayed intervention group receiving the intervention after two rounds of […]

Gareri, Pietro, Putignano, Daria, Castagna, Alberto, Cotroneo, Antonino Maria, De Palo, Grazia, Fabbo, Andrea, Forgione, Luigi, Giacummo, Attilio, Lacava, Roberto, Marino, Saverio, Simone, Maurizio, Zurlo, Amedeo, Putignano, Salvatore

Background: Combined therapy of memantine and acetylcholinesterase inhibitors (AChEIs) in patients with Alzheimer’s disease (AD) may be associated with higher benefits than either monotherapy.; Objective: This retrospective multicentric study conducted in seven Italian Ambulatory Centers for Dementia assessed the efficacy and safety of memantine 20 mg/day administered for 6 months in addition to an AChEI […]