This database contains 536 studies, archived under the term: "psychology"
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Cognitive, emotional, and social benefits of regular musical activities in early dementia: randomized controlled study
Sarkamo, T.,
Tervaniemi, M.,
Laitinen, S.,
Numminen, A.,
Kurki, M.,
Johnson, J. K.,
Rantanen, P.
PURPOSE OF THE STUDY: During aging, musical activities can help maintain physical and mental health and cognitive abilities, but their rehabilitative use has not been systematically explored in persons with dementia (PWDs). Our aim was to determine the efficacy of a novel music intervention based on coaching the caregivers of PWDs to use either singing […]
Differences in regional brain metabolism associated with specific formulations of hormone therapy in postmenopausal women at risk for AD
Silverman, Daniel H. S.,
Geist, Cheri L.,
Kenna, Heather A.,
Williams, Katherine,
Wroolie, Tonita,
Powers, Bevin,
Brooks, John,
Rasgon, Natalie L.
Differential cerebral metabolic effects of various hormone therapy formulations, and their associations with cognitive status, remain to be established. The principal aim of the current study was to assess relationships between regional cerebral metabolism and estrogen-based hormone therapies. Postmenopausal women (n=53) at elevated risk for Alzheimer’s disease (AD) were on estrogen-containing hormone therapy for at […]
A new combined strategy to implement a community occupational therapy intervention: designing a cluster randomized controlled trial
Döpp, Carola M. E.,
Graff, Maud J. L.,
Teerenstra, Steven,
Adang, Eddy,
Nijhuis-van der Sanden, Ria W. G.,
Olderikkert, Marcel G. M.,
Vernooij-Dassen, Myrra J. F. J.
Background: Even effective interventions for people with dementia and their caregivers require specific implementation efforts. A pilot study showed that the highly effective community occupational therapy in dementia (COTiD) program was not implemented optimally due to various barriers. To decrease these barriers and make implementation of the program more effective a combined implementation (CI) strategy […]
A randomized pilot clinical trial of the safety of pioglitazone in treatment of patients with Alzheimer disease
Objectives: To evaluate the safety of the peroxisome proliferator-activated receptor gamma agonist pioglitazone in nondiabetic patients with Alzheimer disease (AD) and to explore treatment effect sizes on clinical outcomes.; Design: Double-blind, placebo-controlled randomized controlled trial of 18-month duration.; Setting: Two academic medical center outpatient clinics.; Patients: Nondiabetic patients meeting research criteria for probable AD were […]
Double-blind, controlled phase II study of a 5-HT6 receptor antagonist, SB-742457, in Alzheimer’s disease
Maher-Edwards, G.,
Zvartau-Hind, M.,
Hunter, A. J.,
Gold, M.,
Hopton, G.,
Jacobs, G.,
Davy, M.,
Williams, P.
Background: This randomized, double-blind, placebo-controlled study investigated the efficacy and tolerability of the 5-HT6 receptor antagonist, SB-742457, in subjects with mild-to-moderate probable Alzheimer’s disease (AD).; Methods: Participating subjects had a Mini-Mental State Examination (MMSE) score of 12 to 26 after a 4-week, single-blind, placebo run-in phase, and were randomized (2:1:1:2) to receive placebo, SB-742457 5 […]
Persons with mild or moderate Alzheimer’s disease use a basic orientation technology to travel to different rooms within a day center
Lancioni, Giulio E.,
Perilli, Viviana,
Singh, Nirbhay N.,
O’Reilly, Mark F.,
Sigafoos, Jeff,
Bosco, Andrea,
De Caro, Maria Fara,
Cassano, Germana,
Pinto, Katia,
Minervini, Mauro
This study assessed whether three patients with Alzheimer’s disease could learn to use a basic orientation technology to reach different rooms within a day center. At each travel instance, the technology provided verbal messages (cues) from the room to reach. For the first two patients, the messages were presented at intervals of about 15s. For […]
Improved language performance in Alzheimer disease following brain stimulation
Cotelli, Maria,
Calabria, Marco,
Manenti, Rosa,
Rosini, Sandra,
Zanetti, Orazio,
Cappa, Stefano F.,
Miniussi, Carlo
Objectives: Repetitive transcranial magnetic stimulation (rTMS) has been proposed as a possible treatment for the cognitive deficits associated with Alzheimer disease (AD). The aim of this study was to assess the long-term effects, on cognitive performance, of rTMS applied to the left dorsolateral prefrontal cortex (DLPFC) in AD patients.; Methods: Ten AD patients were randomly […]
Cognition and function in Alzheimer’s disease: identifying the transitions from moderate to severe disease
Background/aims: Cognitive and functional decline define the transition from moderate to severe Alzheimer’s disease (AD); however, specific relationships between deteriorating cognition and functional abilities are less well characterized. Such relationships are important in care planning and understanding patient needs. Objectives of this post hoc analysis of data from a multicenter randomized double-blind placebo-controlled study were […]