Ohnishi, Takashi, Sakiyama, Yojiro, Okuri, Yuichi, Kimura, Yuji, Sugiyama, Nami, Saito, Takayuki, Takahashi, Masayoshi, Kobayashi, Takumi

The prediction of efficacy in long-term treatment of acetylcholinesterase inhibitors (AChEIs) is a major clinical issue, although no consistently strong predictive factors have emerged thus far. The present analyses aimed to identify factors for predicting long-term outcome of galantamine treatment. Analyses were conducted with data from a 24 weeks randomized, double-blind, placebo controlled trial to […]

Malek-Ahmadi, Michael, Davis, Kathryn, Belden, Christine M, Jacobson, Sandra, Sabbagh, Marwan N.

Background: Differentiating amnestic mild cognitive impairment (aMCI) from normal cognition is difficult in clinical settings. Self-reported and informant-reported memory complaints occur often in both clinical groups, which then necessitates the use of a comprehensive neuropsychological examination to make a differential diagnosis. However, the ability to identify cognitive symptoms that are predictive of aMCI through informant-based […]

Caslake, Robert, Summers, Fiona, McConachie, Douglas, Ferris, Catriona, Gordon, Joanna, Harris, Clare, Caie, Linda, Counsell, Carl

Background: Cognitive decline is common in Parkinson’s disease (PD) but may not be adequately identified by the mini-mental state examination (MMSE), which is better suited to Alzheimer’s disease. The mini-mental Parkinson (MMP) examination is a cognitive screening tool designed in French specifically for PD. We aimed to establish the validity and reliability of the English […]

Bahar-Fuchs, Alex, Villemagne, Victor, Ong, Kevin, Chetélat, Gaël, Lamb, Fiona, Reininger, Cornelia B., Woodward, Michael, Rowe, Christopher C.

Assessment of disease biomarkers, particularly the in vivo assessment of amyloid-β (Aβ) burden with positron emission tomography (PET), is gradually becoming central to the diagnosis of mild cognitive impairment (MCI) due to Alzheimer’s disease (AD). However, the incorporation of biomarker evidence to the diagnostic process is currently restricted mainly to research settings. The identification of […]

Arnaldi, Dario, Campus, Claudio, Ferrara, Michela, Famà, Francesco, Picco, Agnese, De Carli, Fabrizio, Accardo, Jennifer, Brugnolo, Andrea, Sambuceti, Gianmario, Morbelli, Silvia, Nobili, Flavio

Subtle cognitive impairment can be detected in early Parkinson’s disease (PD). In a consecutive series of de novo, drug-naive PD patients, we applied stepwise regression analysis to assess which clinical, neuropsychological, and functional neuroimaging (dopamine transporter [DAT] and perfusion single photon emission computed tomography [SPECT]) characteristics at baseline was predictive of cognitive decline during an […]

Annweiler, C., Rolland, Y., Schott, A.M., Blain, H., Vellas, B., Beauchet, O.

Background: Hypovitaminosis D has been cross-sectionally associated with dementia and stroke. The objective of this longitudinal study was to determine whether serum vitamin D deficiency at baseline could predict the onset of non-Alzheimer dementias (NAD) within 7 years among older women.; Methods: Forty high-functioning older women (78.4 years, 76.4/82.0; median, 25th/75th percentile) from the EPIDOS […]

Anderson, Steven W., Aksan, Nazan, Dawson, Jeffrey D., Uc, Ergun Y., Johnson, Amy M., Rizzo, Matthew

Decline in cognitive abilities can be an important contributor to the driving problems encountered by older adults, and neuropsychological assessment may provide a practical approach to evaluating this aspect of driving safety risk. The purpose of the present study was to evaluate several commonly used neuropsychological tests in the assessment of driving safety risk in […]