Napryeyenko, Oleksandr, Sonnik, Grigoriy, Tartakovsky, Igor

Secondary analyses of a randomised controlled trial were performed to find out whether treatment effects of Ginkgo biloba extract EGb 761 differed by type of dementia. Three hundred ninety-five patients aged 50 years or above, with dementia with neuropsychiatric features were treated with EGb 761 (240 mg/day) or placebo for 22 weeks. Patients scored between […]

Yancheva, S., Ihl, R., Nikolova, G., Panayotov, P., Schlaefke, S., Hoerr, R.

Objective: This randomised, double-blind exploratory trial was undertaken to compare treatment effects and tolerability of EGb 761(R), donepezil and combined treatment in patients with AD and neuropsychiatric features.; Method: We enrolled 96 outpatients, aged 50 years or above, who met the NINCDS/ADRDA criteria for probable AD, scored below 36 on the TE4D, a screening test […]

Vellas, Bruno, Coley, Nicola, Ousset, Pierre-Jean, Berrut, Gilles, Dartigues, Jean-François, Dubois, Bruno, Grandjean, Hélène, Pasquier, Florence, Piette, François, Robert, Philippe, Touchon, Jacques, Garnier, Philippe, Mathiex-Fortunet, Hélène, Andrieu, Sandrine

Background: Prevention strategies are urgently needed to tackle the growing burden of Alzheimer’s disease. We aimed to assess efficacy of long-term use of standardised ginkgo biloba extract for the reduction of incidence of Alzheimer’s disease in elderly adults with memory complaints.; Methods: In the randomised, parallel-group, double-blind, placebo-controlled GuidAge clinical trial, we enrolled adults aged […]

Lewis, John E., McDaniel, H. Reginald, Agronin, Marc E., Loewenstein, David A., Riveros, Jorge, Mestre, Rafael, Martinez, Mairelys, Colina, Niurka, Abreu, Dahlia, Konefal, Janet, Woolger, Judi M., Ali, Karriem H.

Alzheimer’s disease (AD) is a leading killer of Americans, imparts a significant toll on the quality of life of the patient and primary caregiver, and results in inordinate costs in an already overburdened medical system. Prior studies on cholinesterase inhibitors among AD patients have shown minimal amelioration of disease symptoms and/or restoration of lost cognitive […]