Guo, Ming-Dong, Zhou, Wen-Quan, Wei, Yun

Objective:; To observe clinical curative effect of Shenxiong Bushen Capsule for the treatment of mild vascular dementia (VaD), and probe the partial mechanism.; Methods: With a block random, double-blinded and controled clinical research method adopted, seventy patients with VaD were randomly assigned to two groups in a ratio of 5:2, including 50 cases in the […]

Chen, Lie, Huang, Junying, Xue, Li

Objective: To observe the clinical effect of compound Polygonum multiflorum extract on Alzheimer’s disease (AD).; Methods: We collected 209 AD patients, among whom 120 were treated with compound Polygonum multiflorum extract as a treatment group, 60 were treated with Polygonum multiflorum extract as a Chinese herb control group, and 29 were treated with Naofukang as […]

Akhondzadeh, S., Sabet, M. Shafiee, Harirchian, M. H., Togha, M., Cheraghmakani, H., Razeghi, S., Hejazi, S. Sh, Yousefi, M. H., Alimardani, R., Jamshidi, A., Zare, F., Moradi, A.

What Is Known: Herbal medicines have been used in the treatment of behavioural and psychological symptoms of dementia but with variable response. Crocus sativus (saffron) may inhibit the aggregation and deposition of amyloid β in the human brain and may therefore be useful in Alzheimer’s disease (AD).; Objective: The goal of this study was to […]

Bäurle, Peter, Suter, Andy, Wormstall, Henning

Background: In Chinese medicine, Ginkgo biloba is used for a variety of indications. In the current study, the safety and efficacy of a traditional fresh plant extract was investigated in patients with mild cognitive impairment.; Patients and Methods: 59 elderly patients were treated for 6 weeks with a twice daily tablet containing 90 mg of […]

Krikorian, Robert, Nash, Tiffany A., Shidler, Marcelle D., Shukitt-Hale, Barbara, Joseph, James A.

Concord grape juice contains polyphenol compounds, which have antioxidant and anti-inflammatory properties and influence neuronal signalling. Concord grape juice supplementation has been shown to reduce inflammation, blood pressure and vascular pathology in individuals with CVD, and consumption of such flavonoid-containing foods is associated with a reduced risk for dementia. In addition, preliminary animal data have […]

Snitz, Beth E., O'Meara, Ellen S., Carlson, Michelle C., Arnold, Alice M., Ives, Diane G., Rapp, Stephen R., Saxton, Judith, Lopez, Oscar L., Dunn, Leslie O., Sink, Kaycee M., DeKosky, Steven T.

Context: The herbal product Ginkgo biloba is taken frequently with the intention of improving cognitive health in aging. However, evidence from adequately powered clinical trials is lacking regarding its effect on long-term cognitive functioning.; Objective: To determine whether G. biloba slows the rates of global or domain-specific cognitive decline in older adults.; Design, Setting, and […]

Vellas, Bruno, Coley, Nicola, Ousset, Pierre-Jean, Berrut, Gilles, Dartigues, Jean-François, Dubois, Bruno, Grandjean, Hélène, Pasquier, Florence, Piette, François, Robert, Philippe, Touchon, Jacques, Garnier, Philippe, Mathiex-Fortunet, Hélène, Andrieu, Sandrine

Background: Prevention strategies are urgently needed to tackle the growing burden of Alzheimer’s disease. We aimed to assess efficacy of long-term use of standardised ginkgo biloba extract for the reduction of incidence of Alzheimer’s disease in elderly adults with memory complaints.; Methods: In the randomised, parallel-group, double-blind, placebo-controlled GuidAge clinical trial, we enrolled adults aged […]