Lautenschlager, Nicola T., Cox, Kay L., Flicker, Leon, Foster, Jonathan K., van Bockxmeer, Frank M., Xiao, Jianguo, Greenop, Kathryn R., Almeida, Osvaldo P.

Context: Many observational studies have shown that physical activity reduces the risk of cognitive decline; however, evidence from randomized trials is lacking. Objective: To determine whether physical activity reduces the rate of cognitive decline among older adults at risk. Design and Setting: Randomized controlled trial of a 24-week physical activity intervention conducted between 2004 and […]

Okonkwo, O. C., Schultz, S. A., Oh, J. M., Larson, J., Edwards, D., Cook, D., Koscik, R., Gallagher, C. L., Dowling, N. M., Carlsson, C. M., Bendlin, B. B., LaRue, A., Rowley, H. A., Christian, B. T., Asthana, S., Hermann, B. P., Johnson, S. C., Sager, M. A.

Objective: To examine whether engagement in physical activity might favorably alter the agedependent evolution of Alzheimer disease (AD)-related brain and cognitive changes in a cohort of at-risk, late-middle-aged adults. Methods: Three hundred seventeen enrollees in the Wisconsin Registry for Alzheimer’s Prevention underwent T1 MRI; a subset also underwent ¹¹C-Pittsburgh compound B–PET (n = 186) and […]

Smith, J. Carson, Nielson, Kristy A., Woodard, John L., Seidenberg, Michael, Durgerian, Sally, Hazlett, Kathleen E., Figueroa, Christina M., Kandah, Cassandra C., Kay, Christina D., Matthews, Monica A., Rao, Stephen M.

We examined the impact of physical activity (PA) on longitudinal change in hippocampal volume in cognitively intact older adults at varying genetic risk for the sporadic form of Alzheimer’s disease (AD). Hippocampal volume was measured from structural magnetic resonance imaging (MRI) scans administered at baseline and at an 18-month follow-up in 97 healthy, cognitively intact […]

Robitaille, Annie, Muniz, Graciela, Lindwall, Magnus, Piccinin, Andrea M., Hoffman, Lesa, Johansson, Boo, Hofer, Scott M.

The current study examines the role of social contact intensity, cognitive activity, and depressive symptoms as within- and between-person mediators for the relationships between physical activity and cognitive functioning. All three types of mediators were considered simultaneously using multilevel structural equations modeling with longitudinal data. The sample consisted of 470 adults ranging from 79.37 to […]

Lowery, David, Cerga-Pashoja, Arlinda, Iliffe, Steve, Thuné-Boyle, Ingela, Griffin, Mark, Lee, James, Bailey, Alex, Bhattacharya, Rahul, Warner, James

Objective: The objective of this study is to evaluate the effectiveness of a simple dyadic (person with dementia and their main carer) exercise regimen as a therapy for the behavioural and psychological symptoms of dementia. Method: A two arm, pragmatic, randomised, controlled, single‐blind, parallel‐group trial of a dyadic exercise regimen (individually tailored walking regimen designed […]

Dannhauser, Thomas M., Cleverley, Martin, Whitfield, Tim J., Fletcher, Ben, Stevens, Tim, Walker, Zuzana

Background: Dementia affects 35 million people worldwide and is currently incurable. Many cases may be preventable because regular participation in physical, mental and social leisure activities during middle age is associated with up to 47% dementia risk reduction. However, the majority of middle-aged adults are not active enough. MCI is therefore a clear target for […]

Cox, Kay L., Flicker, Leon, Almeida, Osvaldo P., Xiao, Jianguo, Greenop, Kathryn R., Hendriks, Jacqueline, Phillips, Michael, Lautenschlager, Nicola T.

Objective: The aim of this study is to assess in older adults with memory complaints, the effects of a 6-month home-based physical activity (PA) intervention on short-term adherence, short and long-term self-efficacy and the predictors of adherence.; Methods: Participants with memory complaints with or without mild cognitive impairment (MCI) were recruited from Perth, Western Australia […]