Kessels, Roy P. C., Hensken, Linda M. G. Olde

This pilot study examines whether learning without errors is advantageous compared to trial-and-error learning in people with dementia using a procedural task and a randomized case-control design. A sample of 60 people was recruited, consisting of 20 patients with severe dementia, 20 patients with mild-to-moderate dementia and 20 participants without dementia. The participants had to […]

Carr, David B., Barco, Peggy P., Wallendorf, Michael J., Snellgrove, Carol A., Ott, Brian R.

Objectives: To develop a cognitive and functional screening battery for the on-road performance of older drivers with dementia.; Design: Prospective observational study.; Setting: On-road driving evaluation clinic at an academic rehabilitation center.; Participants: Ninety-nine older people with dementia (63% male, mean age 74.2 ± 9), referred by community physicians to an occupational therapy driving clinic.; […]

Zieschang, Tania, Schwenk, Michael, Oster, Peter, Hauer, Klaus

Evidence for sustainability of motor training effects in people with dementia is lacking. To examine whether the substantial improvements in motor performance achieved through a three-month specialized, standardized motor training were sustained, the participants of the randomized controlled trial were re-evaluated nine months after training had ceased. As part of a comprehensive study, participants with […]

Uemura, T., Ishii, K., Miyamoto, N., Yoshikawa, T.

Background and Purpose: Recently, voxel-based statistical parametric images have been developed as additional diagnostic tools for AD. However these methods require the generation of a data base of healthy brain images. The purpose of this study was to produce and evaluate an automatic method using a data base-independent estimation system for the diagnosis of mild […]

Schwenk, M., Zieschang, T., Oster, P., Hauer, K.

Background: Deficits in attention-related cognitive performance measured as dual-task performance represent early markers of dementia and are associated with motor deficits and increased risk of falling. The purpose of this study was to examine the effect of a specific dual-task training in patients with mild to moderate dementia.; Methods: Sixty-one geriatric patients with confirmed dementia […]

Rosas, H. D., Doros, G., Gevorkian, S., Malarick, K., Reuter, M., Coutu, J.-P., Triggs, T. D., Wilkens, P. J., Matson, W., Salat, D. H., Hersch, S. M.

Objective: To assess the safety and tolerability of high-dose creatine, the feasibility of enrolling premanifest and 50% at-risk subjects in a prevention trial, and the potential of cognitive, imaging, and blood markers.; Methods: Sixty-four eligible consenting participants were randomly allocated (1:1) to 15 g twice daily of creatine monohydrate or placebo for a 6-month double-blind […]