Wouters, C. J., Dautzenberg, L., Thissen, A., Dautzenberg, P. L. J.

Objectives: Since January 2008 in The Netherlands, two cholinesterase inhibitors, oral galantamine and rivastigmine transdermal patch, are registered as a one-day symptomatic treatment for Alzheimer’s disease. As no head to head study was performed yet, the objective of this study was to describe the daily practice of oral galantamine and rivastigmine transdermal patch in a […]

Taipale, Heidi, Tanskanen, Antti, Koponen, Marjaana, Tolppanen, Anna-Maija, Tiihonen, Jari, Hartikainen, Sirpa

The objective of this study was to investigate the prevalence of acetylcholinesterase inhibitor (AChEI) and memantine use, duration of treatment, concomitant use of these drugs, and factors associated with the discontinuation of AChEI therapy during 2006-2009. We utilized data from a nationwide sample of community-dwelling individuals with a clinically verified Alzheimer’s disease diagnosed during the […]

Rolland, Yves, Andrieu, Sandrine, Crochard, Anne, Goni, Sylvia, Hein, Christophe, Vellas, Bruno

Objectives: To quantify transitions of residents into or out of nursing homes (NHs) and to describe psychotropic drug prescription at admission and discharge and with regard to dementia diagnosis.; Design: A descriptive, cross-sectional, noninterventional study.; Setting: The setting included 300 NH in France.; Participants: Participants included 2231 NH residents.; Measurements: Participants reported the number, origin, […]

Richter, Tanja, Mann, Eva, Meyer, Gabriele, Haastert, Burkhard, Köpke, Sascha

Background: Despite increasing knowledge about the limited effectiveness and severe adverse effects, the prescription rate of psychotropic medications in frail elderly persons remains high. Prescriptions are mainly made to control behavioral and psychological symptoms of dementia, although factors associated with prescriptions are rarely reported. However, such information is a prerequisite to develop intervention programs aiming […]

Parsons, Carole, McCann, Laura, Passmore, Peter, Hughes, Carmel

Background: No studies have been conducted in the UK context to date that categorise medications in terms of appropriateness for patients with advanced dementia, or that examine medication use in these vulnerable patients. Objectives: The objectives of this study were to categorise the appropriateness of a comprehensive list of medications and medication classes for use […]

Koyama, Alain, Steinman, Michael, Ensrud, Kristine, Hillier, Teresa A., Yaffe, Kristine

Objectives: To determine which older adults tend to receive potentially inappropriate medications (PIMs), how this may differ according to cognitive status, and how the trajectories of PIM use change over time. Design: Ten-year longitudinal cohort study. Setting: Three clinical sites in the United States. Participants: One thousand four hundred eighty-four community-dwelling women aged 75 and […]

Herrmann, Nathan, Binder, Carin, Dalziel, William, Smyth, Steve, Camacho, Fernando

Objective: To determine if choice of drug and ease of administration affect persistence of therapy with cholinesterase inhibitors (ChEIs) for treatment of dementia.; Methods: An observational administrative health database study was conducted in 5622 patients aged >or=65 years who received a new prescription for donepezil (DON), rivastigmine (RIV) or galantamine (GAL) from February to May […]

Choi, Seong Hye, Park, Kyung Won, Na, Duk L., Han, Hyun Jeong, Kim, Eun-Joo, Shim, Yong S., Lee, Jae-Hong, The EXPECT Study Group,

Objective: To compare the tolerability and efficacy of combination therapy of memantine plus rivastigmine patch with rivastigmine patch monotherapy in patients with mild to moderate Alzheimer’s disease (AD).; Research Design and Methods: In this multicenter, randomized, open-label study, patients entered an 8-week run-in period (a 5 cm 2 rivastigmine patch for 4 weeks, then a […]