This database contains 15 studies, archived under the term: "major depression"
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A home‐based training program improves Taiwanese family caregivers’ quality of life and decreases their risk for depression: A randomized controlled trial
Kuo, Li-Min,
Huang, Huei-Ling,
Huang, Hsiu-Li,
Liang, Jersey,
Chiu, Yi-Chen,
Chen, Sien-Tsong,
Kwok, Yam-Ting,
Hsu, Wen-Chuin,
Shyu, Yea-Ing L.
Objectives: Little is known about the longitudinal effects of training programs on family caregivers’ health-related quality of life (HRQoL) and depressive symptoms over time. Therefore, the purpose of this study was to examine the effects of a home-based caregiver training program on HRQoL and depressive symptoms for family caregivers of older persons with dementia. Methods: […]
Problem adaptation therapy for older adults with major depression and cognitive impairment: A randomized clinical trial
Kiosses, Dimitris N.,
Ravdin, Lisa D.,
Gross, James J.,
Raue, Patrick,
Kotbi, Nabil,
Alexopoulos, George S.
IMPORTANCE: Problem adaptation therapy (PATH) is a treatment for older adults with major depression, cognitive impairment (from mild cognitive deficits to moderate dementia), and disability. Antidepressants have limited efficacy in this population and psychosocial interventions are inadequately investigated. OBJECTIVE: To test the efficacy of 12-week PATH vs supportive therapy for cognitively impaired patients (ST-CI) in […]
Safety, tolerability, and efficacy of PBT2 in Huntington’s disease: A phase 2, randomised, double-blind, placebo-controlled trial
Background: PBT2 is a metal protein-attenuating compound that might reduce metal-induced aggregation of mutant huntingtin and has prolonged survival in a mouse model of Huntington’s disease. We aimed to assess the safety, tolerability, and efficacy of PBT2 in patients with Huntington’s disease. Methods: In this 26-week, randomised, double-blind, placebo-controlled trial, adults (≥ 25 years old) […]
Effects of problem solving therapy on mental health outcomes in family caregivers of persons with a new diagnosis of mild cognitive impairment or early dementia: A randomized controlled trial
Garand, Linda,
Rinaldo, Donna E.,
Alberth, Mary M.,
Delany, Jill,
Beasock, Stacey L.,
Lopez, Oscar L.,
Reynolds, Charles F.,
Dew, Mary Amanda
Objective: Interventions directed at the mental health of family dementia caregivers may have limited impact when focused on caregivers who have provided care for years and report high burden levels. We sought to evaluate the mental health effects of problem-solving therapy (PST), designed for caregivers of individuals with a recent diagnosis of Mild Cognitive Impairment […]