This database contains 21 studies, archived under the term: "in"
Click here to filter this large number of results.
The association between mild cognitive impairment and doing housework
Objectives: The ability to perform instrumental activities of daily living (IADL) is thought to be relatively intact for people with mild cognitive impairment (MCI). Doing housework as part of IADL is an important skill needed for older people to live independently and successfully. A limited number of studies explore the association between MCI and doing […]
Video decision support tool for advance care planning in dementia: randomised controlled trial
Volandes, Angelo E.,
Paasche-Orlow, Michael K.,
Barry, Michael J.,
Gillick, Muriel R.,
Minaker, Kenneth L.,
Chang, Yuchiao,
Cook, E. Francis,
Abbo, Elmer D.,
El-Jawahri, Areej,
Mitchell, Susan L.
Objective: To evaluate the effect of a video decision support tool on the preferences for future medical care in older people if they develop advanced dementia, and the stability of those preferences after six weeks.; Design: Randomised controlled trial conducted between 1 September 2007 and 30 May 2008. Setting Four primary care clinics (two geriatric […]
Tailored educational intervention for primary care to improve the management of dementia: the EVIDEM-ED cluster randomized controlled trial
Wilcock, Jane,
Iliffe, Steve,
Griffin, Mark,
Jain, Priya,
Thuné-Boyle, Ingela,
Lefford, Frances,
Rapp, David
Background: Early diagnosis of dementia is important because this allows those with dementia and their families to engage support and plan ahead. However, dementia remains underdetected and suboptimally managed in general practice. Our objective was to test the effect of a workplace-based tailored educational intervention developed for general practice on the clinical management of people […]
Accelerated cognitive decline in patients with type 2 diabetes: MRI correlates and risk factors
Reijmer, Yael D.,
van den Berg, Esther,
de Bresser, Jeroen,
Kessels, Roy P. C.,
Kappelle, L. Jaap,
Algra, Ale,
Biessels, Geert Jan
Background: Type 2 diabetes mellitus is associated with an increased risk of cognitive decline and dementia. We examined brain imaging correlates and vascular and metabolic risk factors of accelerated cognitive decline in patients with type 2 diabetes.; Methods: Cognitive functioning and brain volume as well as metabolic and vascular risk factors were assessed twice in […]
Ingestion of Chlorella reduced the oxidation of erythrocyte membrane lipids in senior Japanese subjects
Miyazawa, Taiki,
Nakagawa, Kiyotaka,
Takekoshi, Hideo,
Higuchi, Ohki,
Kato, Shunji,
Kondo, Momoko,
Kimura, Fumiko,
Miyazawa, Teruo
Accumulation of phospholipid hydroperoxide (PLOOH) in erythrocyte membranes is an abnormality found in patients with senile dementia, including those with Alzheimer’s disease. In our previous studies, dietary xanthophylls (polar carotenoids such as lutein) were hypothesized to inhibit lipid peroxidation. In the present study, we conducted a randomized, double-blind, placebo-controlled human trial to assess the impact […]
Dopamine D₂-agonist rotigotine effects on cortical excitability and central cholinergic transmission in Alzheimer’s disease patients
Martorana, Alessandro,
Di Lorenzo, Francesco,
Esposito, Zaira,
Lo Giudice, Temistocle,
Bernardi, Giorgio,
Caltagirone, Carlo,
Koch, Giacomo
Dopamine is a neurotransmitter involved in several brain functions ranging from emotions control, movement organization to memory formation. It is also involved in the regulation of mechanisms of synaptic plasticity. However, its role in Alzheimer’s disease (AD) pathogenesis is still puzzling. Several recent line of research instead indicates a clear role for dopamine in both […]
Self-regulated music stimulation for persons with Alzheimer’s disease: impact assessment and social validation
Lancioni, Giulio E.,
Singh, Nirbhay N.,
O’Reilly, Mark F.,
Green, Vanessa A.,
Ferlisi, Gabriele,
Ferrarese, Giacomina,
Zullo, Valeria,
Perilli, Viviana,
Cassano, Germana,
Cordiano, Noemi,
Pinto, Katia,
Zonno, Nadia
Objective: To assess the impact and the social rating of an active music condition (in which 10 patients with Alzheimer’s disease regulated their music input) vs. a passive music condition.; Method: In the active condition, the patients used a simple hand response and a microswitch to activate music stimulation periods. In the passive condition, music […]
Cognitive effects of reducing anticholinergic drug burden in a frail elderly population: a randomized controlled trial
Kersten, H.,
Molden, E.,
Tolo, I. K.,
Skovlund, E.,
Engedal, K.,
Wyller, T. B.
Background: Observational studies report a relationship between anticholinergic drug scale (ADS) score and cognitive function. This study investigated whether a reduced ADS score improved cognitive function in a frail elderly population.; Methods: This randomized, controlled, single-blinded trial, recruited long-term residents with an ADS score of greater than or equal to 3 from 22 nursing homes […]