Carlsson, Cynthia M., Xu, Guofan, Wen, Zhifei, Barnet, Jodi H., Blazel, Hanna M., Chappell, Richard J., Stein, James H., Asthana, Sanjay, Sager, Mark A., Alsop, David C., Rowley, Howard A., Fain, Sean B., Johnson, Sterling C.

Background/aims: Hypercholesterolemia in midlife increases risk for Alzheimer’s disease (AD) and contributes to cerebrovascular dysregulation – an early finding in preclinical AD pathology. Statins improve vascular reactivity, but it is unknown if they increase regional cerebral blood flow (CBF) in individuals at risk for AD.; Methods: In a randomized, controlled, double-blind pilot study, 16 asymptomatic […]

Serrano-Pozo, Alberto, Vega, Gloria L., Lütjohann, Dieter, Locascio, Joseph J., Tennis, Marsha K., Deng, Amy, Atri, Alireza, Hyman, Bradley T., Irizarry, Michael C., Growdon, John H.

Preclinical and epidemiologic studies suggest a protective effect of statins on Alzheimer disease (AD). Experimental evidence indicates that some statins can cross the blood-brain barrier, alter brain cholesterol metabolism, and may ultimately decrease the production of amyloid-beta (Abeta) peptide. Despite these promising leads, clinical trials have yielded inconsistent results regarding the benefits of statin treatment […]

Richard, Edo, Van den Heuvel, Esther, Moll van Charante, Eric P., Achthoven, Lenny, Vermeulen, Marinus, Bindels, Patrick J., van Gool, Willem A.

Background and Purpose: Cardiovascular risk factors are associated with an increased risk of dementia. Treatment of hypertension and hypercholesterolemia is associated with a decrease in incident dementia. Whether interventions aimed at cardiovascular risk factors in late life also reduce dementia risk is unknown. Here, we report the outline of a pragmatic study that will attempt […]

Williamson, Jeff D., Launer, Lenore J., Bryan, R. Nick, Coker, Laura H., Lazar, Ronald M., Gerstein, Hertzel C., Murray, Anne M., Sullivan, Mark D., Horowitz, Karen R., Ding, Jingzhong, Marcovina, Santica, Lovato, Laura, Lovato, James, Margolis, Karen L., Davatzikos, Christos, Barzilay, Joshua, Ginsberg, Henry N., Linz, Peter E., Miller, Michael E.

Importance: Persons with type 2 diabetes mellitus (T2DM) are at increased risk for decline in cognitive function, reduced brain volume, and increased white matter lesions in the brain. Poor control of blood pressure (BP) and lipid levels are risk factors for T2DM-related cognitive decline, but the effect of intensive treatment on brain function and structure […]

Martínez Romero, G., Peris Martí, J.F., Gomar Fayos, J., Navarro Gosalbez, M., Quintana Vargas, I., Muelas Tirado, J.

Objectives: Describe and evaluate atypical antipsychotics utilisation on the institutionalized elderly population of the Valencian Community and prevalence of associated metabolic alterations.; Material and Methods: Multicentre transversal descriptive study on medication utilisation and prevalence case-control of alterations of glycaemia, cholesterol and triglycerides. The statistical analysis of metabolic alterations is performed from the difference in prevalence […]

Hyttinen, Laura, TuulioHenriksson, Annamari, Vuorio, Alpo F., Kuosmanen, Noora, Härkänen, Tommi, Koskinen, Seppo, Strandberg, Timo E.

The cognitive status of aged familial hypercholesterolemia (FH) patients treated with long-term statin therapy was compared with that of population controls. A comprehensive cohort of 43 elderly (age > or = 65 years) patients all with the same FH North Karelia mutation living in North Karelia (eastern Finland) was identified, 37 of whom (aged 65 […]