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This database contains 1231 studies, archived under the term: "humans"

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Home blood pressure measurement in elderly patients with cognitive impairment: comparison of agreement between relative-measured blood pressure and automated blood pressure measurement
Objectives: Home blood pressure measurement (HBPM) is recommended by guidelines for hypertension management. However, this method might be difficult to use in elderly individuals with cognitive disorders. Our aim was to assess the agreement and the feasibility of HBPM by a relative as compared with 24-h ambulatory blood pressure monitoring (ABPM) in elderly patients with […]

Contribution of relaxation to a psychoeducational intervention program for family carers of persons with Alzheimer’s disease
Unlabelled: Family caregivers of people with Alzheimer’s disease are at high risk of psychological and physical morbidity due to the daily caring experience.; Objectives: to evaluate the impact of a psychoeducational program involving relaxation techniques on caregivers’ burden and mental health status.; Methods: in this prospective study, 50 family caregivers were randomly assigned to one […]

Effects of the Finnish Alzheimer disease exercise trial (FINALEX): a randomized controlled trial
Importance: Few rigorous clinical trials have investigated the effectiveness of exercise on the physical functioning of patients with Alzheimer disease (AD).; Objectives: To investigate the effects of intense and long-term exercise on the physical functioning and mobility of home-dwelling patients with AD and to explore its effects on the use and costs of health and […]

Efficacy of an occupational group therapy in degenerative dementias: a controlled study in the nursing home setting
Objective: We investigated the effectiveness of an occupational group therapy, tailored to dementia patients, performed regularly 6 days a week, on everyday-practical capabilities and dementia-related behavior.; Methods: Fifty-six dementia patients in one nursing home in Northern Bavaria (Germany) were observed for 6 months: 28 patients in a therapy group and 28 patients in a matched […]

Effects of a creative expression intervention on emotions, communication, and quality of life in persons with dementia
Background: Effective nonpharmacological interventions are needed to treat neuropsychiatric symptoms and to improve quality of life for the 5.3 million Americans affected by dementia.; Objective: The purpose of this study was to test the effect of a storytelling program, TimeSlips, on communication, neuropsychiatric symptoms, and quality of life in long-term care residents with dementia.; Methods: […]

Increased pulse pressure linked to dementia: further results from the Hypertension in the Very Elderly Trial – HYVET
Objectives: High blood pressure (BP) has been associated with increased risk of dementia. Concerns have been raised about lowering BP too far in the very elderly and thereby increasing risk. There is some evidence to suggest a potential ‘J’-shaped relationship between DBP and risk of cognitive impairment. This was investigated using data from the HYpertension […]

Video prompting versus other instruction strategies for persons with Alzheimer’s disease
Background/aim: Two studies assessed the effectiveness of video prompting as a strategy to support persons with mild and moderate Alzheimer’s disease in performing daily activities.; Methods: In study I, video prompting was compared to an existing strategy relying on verbal instructions. In study II, video prompting was compared to another existing strategy relying on static […]

Underestimation of cognitive impairment by Mini-Mental State Examination versus the Montreal Cognitive Assessment in patients with transient ischemic attack and stroke: a population-based study
Background and Purpose: The Mini-Mental State Examination (MMSE) is insensitive to mild cognitive impairment and executive function. The more recently developed Montreal Cognitive Assessment (MoCA), an alternative, brief 30-point global cognitive screen, might pick up more cognitive abnormalities in patients with cerebrovascular disease.; Methods: In a population-based study (Oxford Vascular Study) of transient ischemic attack […]

Effects of a restraint minimization program on staff knowledge, attitudes, and practice: a cluster randomized trial
Objectives: To evaluate the effects of a restraint minimization education program on staff knowledge and attitudes and use of physical restraints.; Design: Cluster-randomized controlled trial with nursing units as the basis for randomization.; Setting: Forty group dwelling units for people with dementia.; Participants: At baseline, there were 184 staff and 191 residents in the intervention […]

Prediction of manifest Huntington’s disease with clinical and imaging measures: a prospective observational study
Background: Although the association between cytosine-adenine-guanine (CAG) repeat length and age at onset of Huntington’s disease is well known, improved prediction of onset would be advantageous for clinical trial design and prognostic counselling. We compared various measures for tracking progression and predicting conversion to manifest Huntington’s disease.; Methods: In this prospective observational study, we assessed […]

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