This database contains 1231 studies, archived under the term: "humans"
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Accelerated cognitive decline in patients with type 2 diabetes: MRI correlates and risk factors
Reijmer, Yael D.,
van den Berg, Esther,
de Bresser, Jeroen,
Kessels, Roy P. C.,
Kappelle, L. Jaap,
Algra, Ale,
Biessels, Geert Jan
Background: Type 2 diabetes mellitus is associated with an increased risk of cognitive decline and dementia. We examined brain imaging correlates and vascular and metabolic risk factors of accelerated cognitive decline in patients with type 2 diabetes.; Methods: Cognitive functioning and brain volume as well as metabolic and vascular risk factors were assessed twice in […]
Screening by telephone in the Alzheimer’s disease anti-inflammatory prevention trial
Reckess, Gila Z.,
Brandt, Jason,
Luis, Cheryl A.,
Zandi, Peter,
Martin, Barbara,
Breitner, John C. S.
Compared with in-person assessment methods, telephone screening for dementia and other cognitive syndromes may improve efficiency of large population studies or prevention trials. We used data from the Alzheimer’s Disease Anti-Inflammatory Prevention Trial to compare performance of a four-test Telephone Assessment Battery (TAB) that included the Telephone Interview for Cognitive Status (TICS) to that of […]
Insulin resistance and medial prefrontal gyrus metabolism in women receiving hormone therapy
Rasgon, Natalie L.,
Kenna, Heather A.,
Wroolie, Tonita E.,
Williams, Katherine E.,
DeMuth, Bevin N.,
Silverman, Daniel H. S.
Insulin resistance (IR) is a putative risk factor for cognitive decline and dementia, and has been shown to impede neuronal glucose metabolism in animal models. This post hoc study focused on metabolic changes in the medial prefrontal region, a brain region exhibiting decline years before documented cognitive changes, relative to high or low IR status […]
Validation of a cognitive assessment battery administered over the telephone
Rapp, Stephen R.,
Legault, Claudine,
Espeland, Mark A.,
Resnick, Susan M.,
Hogan, Patricia E.,
Coker, Laura H.,
Dailey, Maggie,
Shumaker, Sally A.
Objectives: To evaluate the validity and reliability of a cognitive test battery and questionnaires administered by telephone.; Design: Observational study; 110 participants randomly assigned to receive two administrations of the same cognitive test battery 6 months apart in one of four combinations (Time 1 administration/Time 2 administration): telephone/telephone, telephone/face to face, face to face/telephone, face […]
Agitation in nursing home residents with dementia (VIDEANT trial): effects of a cluster-randomized, controlled, guideline implementation trial
Rapp, Michael A.,
Mell, Thomas,
Majić, Tomislav,
Treusch, Yvonne,
Nordheim, Johanna,
Niemann-Mirmehdi, Mechthild,
Gutzmann, Hans,
Heinz, Andreas
Objective: To test the effect of a complex guideline-based intervention on agitation and psychotropic prescriptions.; Design, Setting, Participants: Cluster randomized controlled trial (VIDEANT) with blinded assessment of outcome in 18 nursing homes in Berlin, Germany, comprising 304 dementia patients.; Intervention: Training, support, and activity therapy intervention, delivered at the level of each nursing home, focusing […]
Effects of music therapy on psychological symptoms and heart rate variability in patients with dementia. A pilot study
Raglio, Alfredo,
Oasi, Osmano,
Gianotti, Marta,
Manzoni, Veronica,
Bolis, Silvia,
Ubezio, Maria C.,
Gentile, Simona,
Villani, Daniele,
Stramba-Badiale, Marco
We assessed the effects of music therapy (MT) on behavioral and psychological symptoms (BPSD) in dementia associated with changes in physiological parameters, as heart rate (HR) and heart rate variability (HRV). Twenty subjects were randomly assigned to MT treatment or standard care; all patients underwent neuropsychological assessment and ECG Holter recordings before and after the […]
Efficacy of music therapy treatment based on cycles of sessions: a randomised controlled trial
Raglio, A.,
Bellelli, G.,
Traficante, D.,
Gianotti, M.,
Ubezio, M.C.,
Gentile, S.,
Villani, D.,
Trabucchi, M.
We undertook a randomised controlled trial to assess whether a music therapy (MT) scheme of administration, including three working cycles of one month spaced out by one month of no treatment, is effective to reduce behavioural disturbances in severely demented patients. Sixty persons with severe dementia (30 in the experimental and 30 in the control […]
Platelet decline as a predictor of brain injury in HIV infection
Ragin, Ann B.,
D’Souza, Gypsyamber,
Reynolds, Sandra,
Miller, Eric,
Sacktor, Ned,
Selnes, Ola A.,
Martin, Eileen,
Visscher, Barbara R.,
Becker, James T.
An association between platelet decline and increased risk of progression to dementia has been observed in an advanced HIV infection cohort study. This investigation evaluated the prognostic significance of platelet decline for dementia, for psychomotor slowing, and for brain injury, as quantified in vivo, in a much larger population of HIV+ men. Platelet counts and […]
Comparison of the memory performance index with standard neuropsychological measures of cognition
The Mild Cognitive Impairment Screen (MCIS) is a computer-based cognitive assessment designed for clinical and research use in detecting amnestic mild cognitive impairment (aMCI). Performance on the MCIS is reported as the Memory Performance Index (MPI). However, the comparability between the MPI and traditional neuropsychological tests in detecting aMCI, and in differentiating it from Alzheimer’s […]