Kimura, Takemi, Hayashida, Hideki, Murata, Masako, Takamatsu, Junichi

Aim: The behavioral and psychological symptoms of dementia place a heavy burden on caregivers. Antipsychotic drugs, though used to reduce the symptoms, frequently decrease patients’ activities of daily living and reduce their quality of life. Recently, it was suggested that ferulic acid is an effective treatment for behavioral and psychological symptoms. We have also reported […]

Boxer, Adam L., Lipton, Anne M., Womack, Kyle, Merrilees, Jennifer, Neuhaus, John, Pavlic, Danijela, Gandhi, Anisha, Red, Dana, Martin-Cook, Kristen, Svetlik, Doris, Miller, Bruce L.

There are currently no Food and Drug Administration-approved treatments for frontotemporal lobar degeneration (FTLD). The objectives of this study were to explore the tolerability of memantine treatment in FTLD and to monitor for possible effects on behavior, cognition, and function. Forty-three individuals who met clinical criteria for FTLD [21 with frontotemporal dementia (FTD), 13 with […]

Dukart, Juergen, Mueller, Karsten, Horstmann, Annette, Vogt, Barbara, Frisch, Stefan, Barthel, Henryk, Becker, Georg, Möller, Harald E., Villringer, Arno, Sabri, Osama, Schroeter, Matthias L.

FDG-PET ([18F]fluorodeoxyglucose positron emission tomography) is frequently used to improve the differential diagnosis of dementia. However, a fundamental methodological issue of the reference area for the intensity normalization procedure is still unsolved. Here, we systematically compared the two most commonly used normalization methods to the cerebral and to the cerebellar metabolic rate for glucose with […]

Zhang, Yu, Tartaglia, Maria Carmela, Schuff, Norbert, Chiang, Gloria C., Ching, Christopher, Rosen, Howard J., Gorno-Tempini, Maria Luisa, Miller, Bruce L., Weiner, Michael W.

Brain magnetic resonance imaging (MRI) studies have demonstrated regional patterns of brain macrostructural atrophy and white matter microstructural alterations separately in the three major subtypes of frontotemporal lobar degeneration (FTLD), which includes behavioral variant frontotemporal dementia (bvFTD), semantic dementia (SD), and progressive nonfluent aphasia (PNFA). This study was to investigate to what extent the pattern […]

Snowden, Julie S., Hu, Quan, Rollinson, Sara, Halliwell, Nicola, Robinson, Andrew, Davidson, Yvonne S., Momeni, Parastoo, Baborie, Atik, Griffiths, Timothy D., Jaros, Evelyn, Perry, Robert H., Richardson, Anna, Pickering-Brown, Stuart M., Neary, David, Mann, David M. A.

Frontotemporal lobar degeneration (FTLD) is clinically, pathologically and genetically heterogeneous. Recent descriptions of a pathological sub-type that is ubiquitin positive, TDP-43 negative and immunostains positive for the Fused in Sarcoma protein (FUS) raises the question whether it is associated with a distinct clinical phenotype identifiable on clinical grounds, and whether mutations in the Fused in […]