This database contains 48 studies, archived under the term: "exercise"
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Vascular care in patients with Alzheimer’s disease with cerebrovascular lesions-a randomized clinical trial
Objectives: To investigate whether vascular care slows dementia progression in patients with Alzheimer’s disease with cerebrovascular lesions on neuroimaging.; Design: Multicenter randomized controlled clinical trial with 2-year follow-up.; Setting: Neurological and geriatric outpatient clinics in 10 Dutch hospitals: three academic, five teaching, and two midsize community hospitals.; Participants: One hundred thirty community-dwelling patients with mild […]
Mobility training after hip fracture: a randomised controlled trial
Moseley, Anne M.,
Sherrington, Catherine,
Lord, Stephen R.,
Barraclough, Elizabeth,
St George, Rebecca J.,
Cameron, Ian D.
Objective: to compare the effects of two different exercise programmes after hip fracture.; Design: assessor-blinded randomised controlled trial.; Setting: hospital rehabilitation units, with continued intervention at home.; Subjects: 160 people with surgical fixation for hip fracture transferred to inpatient rehabilitation.; Method: in addition to other rehabilitation strategies, the intervention group received a higher dose (60 […]
Midlife cardiovascular risk factors and late cognitive impairment
Virta, Jyri J.,
Heikkilä, Kauko,
Perola, Markus,
Koskenvuo, Markku,
Räihä, Ismo,
Rinne, Juha O.,
Kaprio, Jaakko
Cardiovascular risk factors increase the risk of dementia in later life. The aims of the current study were to assess the effect of multiple midlife cardiovascular risk factors on the risk of cognitive impairment in later life, and to assess the validity of the previously suggested CAIDE Study risk score predicting dementia risk 20 years later. […]
Physical activity attenuates age-related biomarker alterations in preclinical AD
Okonkwo, O. C.,
Schultz, S. A.,
Oh, J. M.,
Larson, J.,
Edwards, D.,
Cook, D.,
Koscik, R.,
Gallagher, C. L.,
Dowling, N. M.,
Carlsson, C. M.,
Bendlin, B. B.,
LaRue, A.,
Rowley, H. A.,
Christian, B. T.,
Asthana, S.,
Hermann, B. P.,
Johnson, S. C.,
Sager, M. A.
Objective: To examine whether engagement in physical activity might favorably alter the agedependent evolution of Alzheimer disease (AD)-related brain and cognitive changes in a cohort of at-risk, late-middle-aged adults. Methods: Three hundred seventeen enrollees in the Wisconsin Registry for Alzheimer’s Prevention underwent T1 MRI; a subset also underwent ¹¹C-Pittsburgh compound B–PET (n = 186) and […]
How Can we provide better services for demented nursing home residents suffering from apathy?
Treusch, Yvonne,
Jerosch, Daniela,
Majić, Tomislav,
Heinz, Andreas,
Gutzmann, Hans,
Rapp, Michael
Behavioural and psychological symptoms of Dementia include agitation, depression and apathy. Apathy is a common condition and a major challenge especially in nursing home residents. The development of a brief intervention for nursing home residents combining physical activation and reminiscence therapy in order to reactivating apathic residents and increasing their quality of life will be […]
Physical activity reduces hippocampal atrophy in elders at genetic risk for Alzheimer’s disease
Smith, J. Carson,
Nielson, Kristy A.,
Woodard, John L.,
Seidenberg, Michael,
Durgerian, Sally,
Hazlett, Kathleen E.,
Figueroa, Christina M.,
Kandah, Cassandra C.,
Kay, Christina D.,
Matthews, Monica A.,
Rao, Stephen M.
We examined the impact of physical activity (PA) on longitudinal change in hippocampal volume in cognitively intact older adults at varying genetic risk for the sporadic form of Alzheimer’s disease (AD). Hippocampal volume was measured from structural magnetic resonance imaging (MRI) scans administered at baseline and at an 18-month follow-up in 97 healthy, cognitively intact […]