Callahan, Christopher M., Boustani, Malaz A., Schmid, Arlene A., Austrom, Mary G., Miller, Douglas K., Gao, Sujuan, Morris, Carrie S., Vogel, Mickey, Hendrie, Hugh C.

Background: Given the current lack of disease-modifying therapies, it is important to explore new models of longitudinal care for older adults with dementia that focus on improving quality of life and delaying functional decline. In a previous clinical trial, we demonstrated that collaborative care for Alzheimer’s disease reduces patients’ neuropsychiatric symptoms as well as caregiver […]

Dal Bello-Haas, Vanina P. M., Thorpe, Lilian U., Lix, Lisa M., Scudds, Rhonda, Hadjistavropoulos, Thomas

Background: The effects of a regular and graduated walking program as a stand-alone intervention for individuals in long-term care are unclear. Exercise and fall prevention programs typically studied in long-term care settings tend to involve more than one exercise mode, such as a combination of balance, aerobic, strengthening, and flexibility exercises; and, measures do not […]

Arcoverde, Cynthia, Deslandes, Andrea, Moraes, Helena, Almeida, Cloyra, Araujo, Narahyana Bom de, Vasques, Paulo Eduardo, Silveira, Heitor, Laks, Jerson

Objective: To assess the effect of aerobic exercise on the cognition and functional capacity in Alzheimer’s disease (AD) patients.; Method: Elderly (n=20) with mild dementia (NINCDS-ADRDA/CDR1) were randomly assigned to an exercise group (EG) on a treadmill (30 minutes, twice a week and moderate intensity of 60% VO₂max) and control group (GC) 10 patients. The […]

Baker, Laura D., Frank, Laura L., Foster-Schubert, Karen, Green, Pattie S., Wilkinson, Charles W., McTiernan, Anne, Plymate, Stephen R., Fishel, Mark A., Watson, G. Stennis, Cholerton, Brenna A., Duncan, Glen E., Mehta, Pankaj D., Craft, Suzanne

Objectives: To examine the effects of aerobic exercise on cognition and other biomarkers associated with Alzheimer disease pathology for older adults with mild cognitive impairment, and assess the role of sex as a predictor of response.; Design: Six-month, randomized, controlled, clinical trial.; Setting: Veterans Affairs Puget Sound Health Care System clinical research unit.; Participants: Thirty-three […]

Mirelman, Anat, Rochester, Lynn, Reelick, Miriam, Nieuwhof, Freek, Pelosin, Elisa, Abbruzzese, Giovanni, Dockx, Kim, Nieuwboer, Alice, Hausdorff, Jeffrey M.

Background: Recent work has demonstrated that fall risk can be attributed to cognitive as well as motor deficits. Indeed, everyday walking in complex environments utilizes executive function, dual tasking, planning and scanning, all while walking forward. Pilot studies suggest that a multi-modal intervention that combines treadmill training to target motor function and a virtual reality […]