MODEM Dementia Evidence Database

The effectiveness of a stimulation program on cognitive capacity among individuals older than 60

Karatay, G., Akkus, Y.

The purpose of this study was to test the effects of a multistimulant home-based intervention program on cognitive function, anxiety, and depression among older adults with cognitive impairment. This research is quasi-experimental and was designed in an effort to increase the cognitive capacity of individuals above the age of 60 with reduced cognitive capacities. Each […]

Retrospective lifetime dietary patterns predict cognitive performance in community-dwelling older Australians

Hosking, Diane E., Nettelbeck, Ted, Wilson, Carlene, Danthiir, Vanessa

Dietary intake is a modifiable exposure that may have an impact on cognitive outcomes in older age. The long-term aetiology of cognitive decline and dementia, however, suggests that the relevance of dietary intake extends across the lifetime. In the present study, we tested whether retrospective dietary patterns from the life periods of childhood, early adulthood, […]

Ankle blood pressure and dementia: a prospective follow-up study

Hietanen, Heikki, Pietilä, Arto, Kähönen, Mika, Salomaa, Veikko

Background and Objective: Ankle blood pressure may be a useful indicator of arterial stiffness. The main aim of the present study was to examine the relationship of ankle blood pressure measured in midlife with the risk of dementia with advancing age. A secondary aim was to examine the relationship of physical exercise capacity in midlife […]

A randomized, double-blind, placebo-controlled trial of memantine in a behaviorally enriched sample of patients with moderate-to-severe Alzheimer’s disease

Herrmann, Nathan, Gauthier, Serge, Boneva, Neli, Lemming, Ole Michael

Background: Agitation and aggression in Alzheimer’s disease (AD) are amongst the most serious of neuropsychiatric symptoms, and contribute to poor outcomes and worse quality of life. Previous studies have suggested a benefit for memantine on agitation and aggression, but none have examined its efficacy in community-dwelling patients with significant agitation and aggression at baseline, utilizing […]

Persistence with cholinesterase inhibitor therapy for dementia: an observational administrative health database study

Herrmann, Nathan, Binder, Carin, Dalziel, William, Smyth, Steve, Camacho, Fernando

Objective: To determine if choice of drug and ease of administration affect persistence of therapy with cholinesterase inhibitors (ChEIs) for treatment of dementia.; Methods: An observational administrative health database study was conducted in 5622 patients aged >or=65 years who received a new prescription for donepezil (DON), rivastigmine (RIV) or galantamine (GAL) from February to May […]

Effect of the bathing without a battle training intervention on bathing-associated physical and verbal outcomes in nursing home residents with dementia: a randomized crossover diffusion study

Gozalo, Pedro, Prakash, Shivaani, Qato, Danya M., Sloane, Philip D., Mor, Vincent

Objectives: To evaluate the effectiveness of the Bathing Without a Battle intervention in reducing physical and verbal aggressive behaviors for nursing home residents with dementia.; Design: A randomized crossover diffusion study, with one group receiving the intervention after one round of baseline observations and a delayed intervention group receiving the intervention after two rounds of […]

Educational and formative training reduce stress in the caregivers of demented patients

Gelmini, G., Morabito, B., Braidi, G.

The present study has been organized for appraising if the formation of the caregivers of insane patients can bring benefits to the conditions of stress that bear every day. The evaluation has considered 74 caregivers participants to 5 courses of formation organized in 12 evenings of around 2 each. The subjects have been valued before […]

Clinical trial of an inhibitor of RAGE-Aβ interactions in Alzheimer disease

Galasko, D., Bell, J., Mancuso, J. Y., Kupiec, J. W., Sabbagh, M. N., van Dyck, C., Thomas, R. G., Aisen, P. S.

Objective: To examine safety, tolerability, and efficacy of PF-04494700, an inhibitor of the receptor for advanced glycation end products (RAGE), in mild to moderate Alzheimer disease (AD).; Methods: Double-blind, placebo-controlled trial at 40 academic centers (United States). Subjects with AD and Mini-Mental State Examination score 14-26 were randomized to PF-04494700 60 mg/day × 6 days, […]

Cognitive functions in a patient with Parkinson-dementia syndrome undergoing deep brain stimulation

Freund, Hans-Joachim, Kuhn, Jens, Lenartz, Doris, Mai, Jürgen K., Schnell, Thomas, Klosterkoetter, Joachim, Sturm, Volker

Background: Dementia represents one of the most challenging health problems. Despite intense research, available therapies have thus far only achieved modest results. Deep brain stimulation (DBS) is an effective treatment option for some movement disorders and is under study for psychiatric applications. Recently, diencephalic DBS revealed selective effects on memory functions, another facet of subcortical […]

Long-term safety of rivastigmine in parkinson disease dementia: an open-label, randomized study

Emre, Murat, Poewe, Werner, De Deyn, Peter Paul, Barone, Paolo, Kulisevsky, Jaime, Pourcher, Emmanuelle, van Laar, Teus, Storch, Alexander, Micheli, Federico, Burn, David, Durif, Frank, Pahwa, Rajesh, Callegari, Francesca, Tenenbaum, Nadia, Strohmaier, Christine

Objective: This study investigated the long-term safety of rivastigmine (12 mg/d capsules, 9.5 mg/24 h patch) and effects on motor symptoms in patients with mild-to-moderately severe Parkinson disease dementia.; Methods: This was a 76-week, prospective, open-label, randomized study in patients aged 50 to 85 years. Primary outcomes included incidence of, and discontinuation due to, predefined […]

This database contains 173 abstracts archived under the term: "etiology"

This database contains 173 studies, archived under the term: "etiology"