Cazzola, Roberta, Rondanelli, Mariangela, Faliva, Milena, Cestaro, Benvenuto

A randomized, double-blind placebo-controlled clinical trial was carried out to assess the efficacy of a docosahexenoic acid (DHA)-phospholipids, melatonin and tryptophan supplemented diet in improving the erythrocyte oxidative stress, membrane fluidity and membrane-bound enzyme activities of elderly subjects suffering from mild cognitive impairment (MCI). These subjects were randomly assigned to the supplement group (11 subjects, […]

Soto, Maria E., Abellan van Kan, Gabor, Nourhashemi, Fati, Gillette-Guyonnet, Sophie, Cesari, Matteo, Cantet, Christelle, Rolland, Yves, Vellas, Bruno

Objectives: To assess whether angiotensin-converting enzyme inhibitor (ACE-I) treatment is associated with less cognitive decline in older adults with Alzheimer’s disease (AD) than in those using other hypertensive or no drugs.; Design: Four-year prospective multicenter cohort study with a biannual assessment.; Setting: Memory clinics from 16 university hospitals in France.; Participants: Community-dwelling older adults with […]

Sink, Kaycee M., Leng, Xiaoyan, Williamson, Jeff, Kritchevsky, Stephen B., Yaffe, Kristine, Kuller, Lewis, Yasar, Sevil, Atkinson, Hal, Robbins, Mike, Psaty, Bruce, Goff, David C.

Background: Hypertension (HTN) is a risk factor for dementia, and animal studies suggest that centrally active angiotensin-converting enzyme (ACE) inhibitors (those that cross the blood-brain barrier) may protect against dementia beyond HTN control.; Methods: Participants in the Cardiovascular Health Study Cognition Substudy with treated HTN and no diagnosis of congestive heart failure (n = 1054; […]

O'Caoimh, Rónán, Healy, Liam, Gao, Yang, Svendrovski, Anton, Kerins, David M., Eustace, Joseph, Kehoe, Patrick Gavin, Guyatt, Gordon, Molloy, D. William

Background: Centrally acting angiotensin converting enzyme inhibitors (CACE-Is) are associated with reduced rates of cognitive decline in patients with dementia. CACE-Is may also improve exercise tolerance in functionally impaired older adults with normal cognition, suggesting that CACE-Is may positively influence activities of daily living (ADL) in dementia.; Objective: To compare rates of decline in patients […]

Kanagaratnam, Lukshe, Mahmoudi, Rachid, Novella, Jean-Luc, Jolly, Damien, Dramé, Moustapha, Trenque, Thierry

Introduction: Drug prescriptions represent an actionable item in the prevention of adverse drug reactions (ADRs). The aims of this study were to identify risk factors for the occurrence of ADRs, and to describe symptoms and drug interactions. Methods: This was a longitudinal study over a period of 19 months in an acute geriatric ward specializing […]

Hebert, Paul L., McBean, Alexander Marshall, O'Connor, Heidi, Frank, Barbara, Good, Charles, Maciejewski, Matthew L.

Background: Centrally active (CA) angiotensin-converting enzyme inhibitors (ACEIs) are able to cross the blood–brain barrier. Small observational studies and mouse models suggest that use of CA versus non-CA ACEIs is associated with a reduced incidence of Alzheimer’s disease and related dementias (ADRD).; Objective: The aim of this research was to assess the effect of CA […]