Smeets, Claudia H. W., Smalbrugge, Martin, Gerritsen, Debby L, Nelissen-Vrancken, Marjorie H. J. M. G., Wetzels, Roland B., van der Spek, Klaas, Zuidema, Sytse U., Koopmans, Raymond T. C. M.

Background: Neuropsychiatric symptoms are highly prevalent in nursing home patients with dementia. Despite modest effectiveness and considerable side effects, psychotropic drugs are frequently prescribed for these neuropsychiatric symptoms. This raises questions whether psychotropic drugs are appropriately prescribed. The aim of the PROPER (PRescription Optimization of Psychotropic drugs in Elderly nuRsing home patients with dementia) II […]

Taipale, Heidi, Tanskanen, Antti, Koponen, Marjaana, Tolppanen, Anna-Maija, Tiihonen, Jari, Hartikainen, Sirpa

The objective of this study was to investigate the prevalence of acetylcholinesterase inhibitor (AChEI) and memantine use, duration of treatment, concomitant use of these drugs, and factors associated with the discontinuation of AChEI therapy during 2006-2009. We utilized data from a nationwide sample of community-dwelling individuals with a clinically verified Alzheimer’s disease diagnosed during the […]

Lazzeroni, Laura C., Halbauer, Joshua D., Ashford, J. Wesson, Noda, Art, Hernandez, Beatriz, Azor, Virgina, Hozack, Nikki, Hasson, Noelle, Henderson, Victor W., Yesavage, Jerome A., Tinklenberg, Jared R.

Alzheimer’s disease (AD) shortens life-expectancy, but the effects of pharmacological treatments for this disorder on mortality have not been studied. We compared two commonly prescribed medications, donepezil and memantine, with respect to the length of survival of veterans presumed to have AD. The Computerized Medical Records System at the Veterans Affairs Palo Alto Health Care […]