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This database contains 9 studies, archived under the term: "diagnostic and statistical manual of mental disorders"

Factors associated with sustained attention during an activity intervention in persons with dementia

Background/aims: Are the noncognitive factors of self-reported mood and personality related to sustained attention in nursing home residents with dementia during an activity intervention?; Methods: Intervention data from a randomized clinical trial were used to address the aim of this project. Subjects were 128 nursing home residents who were assessed for mood, personality, behavioral indicators […]

Validation of AclarusDx™, a blood-based transcriptomic signature for the diagnosis of Alzheimer’s disease

Biomarkers have gained an increased importance in the past years in helping physicians to diagnose Alzheimer’s disease (AD). This study was designed to identify a blood-based, transcriptomic signature that can differentiate AD patients from control subjects. The performance of the signature was then evaluated for robustness in an independent blinded sample population. RNA was extracted […]

Quality of life and the effect of memantine in dementia with lewy bodies and Parkinson’s disease dementia

Aim: To investigate quality of life (QOL) and the effect of memantine treatment in patients with Lewy body dementias.; Methods: A secondary analysis of a randomized controlled study in 70 patients with Parkinson’s disease dementia (PDD) or dementia with Lewy bodies (DLB) over 24 weeks using caregiver-rated QOL-Alzheimer’s disease (AD) in domains according to the […]

Differential perceptions of quality of life (QoL) in community-dwelling persons with mild-to-moderate dementia

Background: Discordance between patient- and caregiver-reported quality of life (QoL) is well recognized. This study sought to (i) identify predictors of discrepancy between patient- and caregiver-rated QoL amongst community-dwelling persons with mild-to-moderate dementia, and (ii) differentiate between patients who systematically rate their QoL lower versus those who rate their QoL higher relative to their caregiver […]

Antidementia drug use among community-dwelling individuals with Alzheimer’s disease in Finland: a nationwide register-based study

The objective of this study was to investigate the prevalence of acetylcholinesterase inhibitor (AChEI) and memantine use, duration of treatment, concomitant use of these drugs, and factors associated with the discontinuation of AChEI therapy during 2006-2009. We utilized data from a nationwide sample of community-dwelling individuals with a clinically verified Alzheimer’s disease diagnosed during the […]

Evaluation of the effects of galantamine on cardiac function in elderly patients with Alzheimer’s disease

Background: Galantamine, a cholinesterase inhibitor, is used as a first-line drug in the treatment of Alzheimer’s disease (AD). However, it may have vagotonic effects, which may cause bradycardia and/or heart block in patients with or without a history of cardiac disease.; Objective: The purpose of this study was to evaluate the effects of galantamine on […]

Are two methods better than one? Evaluating the effectiveness of combining errorless learning with vanishing cues

A growing trend in memory rehabilitation is to combine learning principles to enhance treatment effects. While this makes intuitive sense, little is known about the added value of incorporating each method. A further complication is that some interventions, although primarily based on one learning principle, actually incorporate several, which again adds to the difficulty in […]

Helping carers to care–the 10/66 dementia research group’s randomized control trial of a caregiver intervention in Russia

Objectives: Dementia is a rapidly growing public health problem in low and middle income countries. There is an urgent need, in the absence of formal services, to develop interventions designed to improve the lives of people with dementia, and their families. This study tests the effectiveness of the 10/66 caregiver intervention among people with dementia, […]

Serum vitamin D deficiency as a predictor of incident non-Alzheimer dementias: a 7-year longitudinal study

Background: Hypovitaminosis D has been cross-sectionally associated with dementia and stroke. The objective of this longitudinal study was to determine whether serum vitamin D deficiency at baseline could predict the onset of non-Alzheimer dementias (NAD) within 7 years among older women.; Methods: Forty high-functioning older women (78.4 years, 76.4/82.0; median, 25th/75th percentile) from the EPIDOS […]

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