Breitner, John C., Baker, Laura D., Montine, Thomas J., Meinert, Curtis L., Lyketsos, Constantine G., Ashe, Karen H., Brandt, Jason, Craft, Suzanne, Evans, Denis E., Green, Robert C., Ismail, M. Saleem, Martin, Barbara K., Mullan, Michael J., Sabbagh, Marwan, Tariot, Pierre N.

Background: Epidemiologic evidence suggests that nonsteroidal anti-inflammatory drugs (NSAIDs) delay onset of Alzheimer’s dementia (AD), but randomized trials show no benefit from NSAIDs in patients with symptomatic AD. The Alzheimer’s Disease Anti-inflammatory Prevention Trial (ADAPT) randomized 2,528 elderly persons to naproxen or celecoxib versus placebo for 2 years (standard deviation = 11 months) before treatments […]

Kiely, Dan K., Givens, Jane L., Shaffer, Michele L., Teno, Joan M., Mitchell, Susan L.

Objectives: To identify characteristics of nursing home (NH) residents with advanced dementia and their healthcare proxies (HCPs) associated with hospice referral and to examine the association between hospice use and the treatment of pain and dyspnea and unmet needs during the last 7 days of life.; Design: Prospective cohort study.; Setting: Twenty-two Boston-area NHs.; Participants: […]

Thompson, Hilaire J., Rivara, Frederick P., Nathens, Avery, Wang, Jin, Jurkovich, Gregory J., Mackenzie, Ellen J.

Objective: The aim of this study was to develop and validate a comorbidity index to predict the risk of mortality associated with chronic health conditions following a traumatic injury.; Summary Background Data: Currently available comorbidity adjustment tools do not account for certain chronic conditions, which may influence outcome following traumatic injury or they have not […]