This database contains 219 studies, archived under the term: "complications"
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Motor effects of REAC in advanced Alzheimer’s disease: results from a pilot trial
Olazarán, Javier,
González, Belén,
López-Álvarez, Jorge,
Castagna, Alessandro,
Osa-Ruiz, Emma,
Herrero-Cano, Vanesa,
Agüera-Ortiz, Luis,
Rinaldi, Salvatore,
Martínez-Martín, Pablo
We conducted a pilot, randomized, controlled trial to mainly investigate the feasibility, safety, and short-term motor effects of brain stimulation with radio electric asymmetric conveyer (REAC) technology in patients with advanced Alzheimer’s disease (AD) who also experience some gait dysfunction. Neuropostural optimization (NPO) or sham protocol was administered to 31 nursing home patients (mean [SD] […]
Effects of Yokukansan on behavioral and psychological symptoms of dementia in regular treatment for Alzheimer’s disease
Okahara, Kazunori,
Ishida, Yasushi,
Hayashi, Yoshihito,
Inoue, Teruhiko,
Tsuruta, Kazuhito,
Takeuchi, Kouzou,
Yoshimuta, Hirofumi,
Kiue, Kouichirou,
Ninomiya, Yoshimasa,
Kawano, Jiro,
Yoshida, Kensei,
Noda, Shouji,
Tomita, Seiichiro,
Fujimoto, Masumi,
Hosomi, Jun,
Mitsuyama, Yoshio
Yokukansan (YKS) is used frequently against behavioral and psychological symptoms of dementia (BPSD) together with donepezil in patients with Alzheimer’s disease (AD). Here, we investigated the efficacy and safety of YKS in patients with AD in a non-blinded, randomized, parallel-group comparison study. Patients who had at least one symptom score of four or more on […]
Effects of music therapy on autonomic nervous system activity, incidence of heart failure events, and plasma cytokine and catecholamine levels in elderly patients with cerebrovascular disease and dementia
Okada, Kaoru,
Kurita, Akira,
Takase, Bonpei,
Otsuka, Toshiaki,
Kodani, Eitaro,
Kusama, Yoshiki,
Atarashi, Hirotsugu,
Mizuno, Kyoichi
Music therapy (MT) has been used in geriatric nursing hospitals, but there has been no extensive research into whether it actually has beneficial effects on elderly patients with cerebrovascular disease (CVD) and dementia. We investigated the effects of MT on the autonomic nervous system and plasma cytokine and catecholamine levels in elderly patients with CVD […]
Effects of centrally acting angiotensin converting enzyme inhibitors on functional decline in patients with Alzheimer’s disease
O'Caoimh, Rónán,
Healy, Liam,
Gao, Yang,
Svendrovski, Anton,
Kerins, David M.,
Eustace, Joseph,
Kehoe, Patrick Gavin,
Guyatt, Gordon,
Molloy, D. William
Background: Centrally acting angiotensin converting enzyme inhibitors (CACE-Is) are associated with reduced rates of cognitive decline in patients with dementia. CACE-Is may also improve exercise tolerance in functionally impaired older adults with normal cognition, suggesting that CACE-Is may positively influence activities of daily living (ADL) in dementia.; Objective: To compare rates of decline in patients […]
Telomere shortening in elderly individuals with mild cognitive impairment may be attenuated with ω-3 fatty acid supplementation: a randomized controlled pilot study
O'Callaghan, Nathan,
Parletta, Natalie,
Milte, Catherine M.,
Benassi-Evans, Bianca,
Fenech, Michael,
Howe, Peter R.C.
Objectives: Excessive shortening of the telomeric ends of chromosomes is a marker of accelerated aging. Oxidative stress and nutritional deficiency may influence this process. The aim of this study was to investigate the effect of ω-3 polyunsaturated fatty acid (ω-3 PUFA) supplementation on telomeric shortening in elderly individuals with mild cognitive impairment (MCI).; Methods: Thirty-three […]
Montreal cognitive assessment performance in patients with Parkinson’s disease with “normal” global cognition according to mini-mental state examination score
Nazem, Sarra,
Siderowf, Andrew D.,
Duda, John E.,
Ten Have, Tom,
Colcher, Amy,
Horn, Stacy S.,
Moberg, Paul J.,
Wilkinson, Jayne R.,
Hurtig, Howard I.,
Stern, Matthew B.,
Weintraub, Daniel
Objectives: To examine Montreal Cognitive Assessment (MoCA) performance in patients with Parkinson’s disease (PD) with “normal” global cognition according to Mini-Mental State Examination (MMSE) score.; Design: A cross-sectional comparison of the MoCA and the MMSE.; Setting: Two movement disorders centers at the University of Pennsylvania and the Philadelphia Veterans Affairs Medical Center.; Participants: A convenience […]
Efficacy of musical interventions in dementia: evidence from a randomized controlled trial
Narme, Pauline,
Clément, Sylvain,
Ehrlé, Nathalie,
Schiaratura, Loris,
Vachez, Sylvie,
Courtaigne, Bruno,
Munsch, Frédéric,
Samson, Séverine
Although musical interventions have recently gained popularity as a non-pharmacological treatment in dementia, there is still insufficient evidence of their effectiveness. To investigate this issue, a single-center randomized controlled trial was conducted with forty-eight patients with Alzheimer’s disease or mixed dementia to compare the effects of music versus cooking interventions in the emotional, cognitive, and […]
A randomized clinical trial of Behavioral Activation (BA) therapy for improving psychological and physical health in dementia caregivers: results of the Pleasant Events Program (PEP)
Moore, Raeanne C.,
Chattillion, Elizabeth A.,
Ceglowski, Jennifer,
Ho, Jennifer,
von Känel, Roland,
Mills, Paul J.,
Ziegler, Michael G.,
Patterson, Thomas L.,
Grant, Igor,
Mausbach, Brent T.
Dementia caregiving is associated with elevations in depressive symptoms and increased risk for cardiovascular diseases (CVD). This study evaluated the efficacy of the Pleasant Events Program (PEP), a 6-week Behavioral Activation intervention designed to reduce CVD risk and depressive symptoms in caregivers. One hundred dementia family caregivers were randomized to either the 6-week PEP intervention […]