Uemura, T., Ishii, K., Miyamoto, N., Yoshikawa, T.

Background and Purpose: Recently, voxel-based statistical parametric images have been developed as additional diagnostic tools for AD. However these methods require the generation of a data base of healthy brain images. The purpose of this study was to produce and evaluate an automatic method using a data base-independent estimation system for the diagnosis of mild […]

Tsai, Pao-Feng, Chang, Jason Y., Beck, Cornelia, Kuo, Yong-Fang, Keefe, Francis J.

Context: Because Tai Chi (TC) is beneficial to elders without cognitive impairment (CI), it also may benefit elders with CI. But elders with CI have generally been excluded from TC studies because many measurement tools require verbal reports that some elders with CI are unable to provide.; Objectives: To test the efficacy of a TC […]

Roque, Marta, Salva, A., Vellas, B.

Objectives: The objective of this study is to assess the nutritional status, measured by the MNA, in community-dwelling elderly individuals with dementia and to identify clinical risk factors for nutritional risk or malnutrition.; Design: Cross-sectional analysis of a cluster randomized clinical trial (Nutrialz).; Setting: Community-dwelling individuals attending dementia clinics.; Participants: 940 individuals.; Measurements: The clinical […]

Richter, Tanja, Mann, Eva, Meyer, Gabriele, Haastert, Burkhard, Köpke, Sascha

Background: Despite increasing knowledge about the limited effectiveness and severe adverse effects, the prescription rate of psychotropic medications in frail elderly persons remains high. Prescriptions are mainly made to control behavioral and psychological symptoms of dementia, although factors associated with prescriptions are rarely reported. However, such information is a prerequisite to develop intervention programs aiming […]

Rapp, Michael A., Mell, Thomas, Majić, Tomislav, Treusch, Yvonne, Nordheim, Johanna, Niemann-Mirmehdi, Mechthild, Gutzmann, Hans, Heinz, Andreas

Objective: To test the effect of a complex guideline-based intervention on agitation and psychotropic prescriptions.; Design, Setting, Participants: Cluster randomized controlled trial (VIDEANT) with blinded assessment of outcome in 18 nursing homes in Berlin, Germany, comprising 304 dementia patients.; Intervention: Training, support, and activity therapy intervention, delivered at the level of each nursing home, focusing […]

Husebo, B. S., Ballard, C., Sandvik, R., Nilsen, O. B., Aarsland, D.

Objective: To determine whether a systematic approach to the treatment of pain can reduce agitation in people with moderate to severe dementia living in nursing homes.; Design: Cluster randomised controlled trial.; Setting: 60 clusters (single independent nursing home units) in 18 nursing homes within five municipalities of western Norway.; Participants: 352 residents with moderate to […]

Eggermont, Laura H.P., Knol, Dirk L., Hol, Elly M., Swaab, Dick F., Scherder, Erik J.A.

Background: Physical activity such as walking may exert a positive impact on cognition and behaviour in older persons with dementia, but due to the frailty of the population it may be worthwhile to consider other motor activities as well.; Objective: Examining the effects of hand motor activity on cognition, mood and the rest-activity rhythm in […]

Bondi, Mark W., Edmonds, Emily C., Jak, Amy J., Clark, Lindsay R., Delano-Wood, Lisa, McDonald, Carrie R., Nation, Daniel A., Libon, David J., Au, Rhoda, Galasko, Douglas, Salmon, David P.

We compared two methods of diagnosing mild cognitive impairment (MCI): conventional Petersen/Winblad criteria as operationalized by the Alzheimer’s Disease Neuroimaging Initiative (ADNI) and an actuarial neuropsychological method put forward by Jak and Bondi designed to balance sensitivity and reliability. 1,150 ADNI participants were diagnosed at baseline as cognitively normal (CN) or MCI via ADNI criteria […]