Paganini, M., Biggeri, A., Romoli, A. M., Mechi, C., Ghelli, E., Berti, V., Pradella, S., Bucciantini, S., Catelan, D., Saccardi, R., Lombardini, L., Mascalchi, M., Massacesi, L., Porfirio, B., Di Lorenzo, N., Vannelli, G. B., Gallina, P.

Objective: To assess the clinical effect of caudate-putaminal transplantation of fetal striatal tissue in Huntington’s disease (HD).; Methods: We carried out a follow-up study on 10 HD transplanted patients and 16 HD not-transplanted patients. All patients were evaluated with the Unified HD Rating Scale (UHDRS) whose change in motor, cognitive, behavioural and functional capacity total […]

Martorana, Alessandro, Di Lorenzo, Francesco, Esposito, Zaira, Lo Giudice, Temistocle, Bernardi, Giorgio, Caltagirone, Carlo, Koch, Giacomo

Dopamine is a neurotransmitter involved in several brain functions ranging from emotions control, movement organization to memory formation. It is also involved in the regulation of mechanisms of synaptic plasticity. However, its role in Alzheimer’s disease (AD) pathogenesis is still puzzling. Several recent line of research instead indicates a clear role for dopamine in both […]

Aresi, Anna, Giovagnoli, Anna Rita

This study investigated the neuropsychological hallmarks of posterior cortical atrophy (PCA). Seventeen patients with PCA, 17 patients with probable Alzheimer’s disease (PAD), and 17 healthy age-matched subjects underwent neuropsychological testing for abstract reasoning, visuospatial abilities, memory, language, executive functions, praxes, and attention. The PCA patients were significantly more impaired in visual perception, spatial memory, visual […]