von Arnim, Christine A. F., Herbolsheimer, Florian, Nikolaus, Thorsten, Peter, Richard, Biesalski, Hans K., Ludolph, Albert C., Riepe, Matthias, Nagel, Gabriele

Oxidative stress is believed to play a central role in the pathogenesis of Alzheimer’s disease (AD), a neurodegenerative disease. Antioxidants may prevent the onset AD as high dietary intake of vitamin C and E were reported to be associated with lower risk of the disease. The objective of this study was to evaluate the serum […]

Polidori, M. Cristina, Praticó, Domenico, Mangialasche, Francesca, Mariani, Elena, Aust, Olivier, Anlasik, Timur, Mang, Ni, Pientka, Ludger, Stahl, Wilhelm, Sies, Helmut, Mecocci, Patrizia, Nelles, Gereon

A higher daily intake of fruits and vegetables in healthy elderly is associated with an improved antioxidant status in comparison to subjects consuming diets poor in fruits and vegetables, but the impact on cognitive performance is unclear. Healthy community dwellers (45 to 102 years old, n=193) underwent cognitive testing and blood withdrawal for the measurement […]

Miyazawa, Taiki, Nakagawa, Kiyotaka, Takekoshi, Hideo, Higuchi, Ohki, Kato, Shunji, Kondo, Momoko, Kimura, Fumiko, Miyazawa, Teruo

Accumulation of phospholipid hydroperoxide (PLOOH) in erythrocyte membranes is an abnormality found in patients with senile dementia, including those with Alzheimer’s disease. In our previous studies, dietary xanthophylls (polar carotenoids such as lutein) were hypothesized to inhibit lipid peroxidation. In the present study, we conducted a randomized, double-blind, placebo-controlled human trial to assess the impact […]