Steffens, David C., McQuoid, Douglas R., Payne, Martha E., Potter, Guy G.

Introduction: previous studies have linked hippocampal volume change and cognitive decline in older adults with dementia. The authors examined hippocampal volume change and cognitive change in older nondemented adults with and without major depression.; Methods: the sample consisted of 90 depressed individuals and 72 healthy, nondepressed individuals aged 60 years and older who completed at […]

Rosas, H. D., Doros, G., Gevorkian, S., Malarick, K., Reuter, M., Coutu, J.-P., Triggs, T. D., Wilkens, P. J., Matson, W., Salat, D. H., Hersch, S. M.

Objective: To assess the safety and tolerability of high-dose creatine, the feasibility of enrolling premanifest and 50% at-risk subjects in a prevention trial, and the potential of cognitive, imaging, and blood markers.; Methods: Sixty-four eligible consenting participants were randomly allocated (1:1) to 15 g twice daily of creatine monohydrate or placebo for a 6-month double-blind […]

Borroni, Barbara, Malinverno, Matteo, Gardoni, Fabrizio, Grassi, Mario, Parnetti, Lucilla, Agosti, Chiara, Alberici, Antonella, Premi, Enrico, Bonuccelli, Ubaldo, Gasparotti, Roberto, Calabresi, Paolo, Di Luca, Monica, Padovani, Alessandro

Cerebrospinal fluid (CSF) tau ratio decrease (33kDa/55kDa forms) and mid-saggital midbrain-to-pons (MP) atrophy have been suggested as diagnostic markers for progressive supranuclear palsy (PSP). The usefulness of their combined evaluation has never been tested. We evaluated the CSF tau ratio and the MP atrophy as a combined marker for early identification of PSP. A total […]

Aresi, Anna, Giovagnoli, Anna Rita

This study investigated the neuropsychological hallmarks of posterior cortical atrophy (PCA). Seventeen patients with PCA, 17 patients with probable Alzheimer’s disease (PAD), and 17 healthy age-matched subjects underwent neuropsychological testing for abstract reasoning, visuospatial abilities, memory, language, executive functions, praxes, and attention. The PCA patients were significantly more impaired in visual perception, spatial memory, visual […]