Rosenberg, Paul B., Lanctôt, Krista L., Drye, Lea T., Herrmann, Nathan, Scherer, Roberta W., Bachman, David L., Mintzer, Jacobo E.

Objective: In a recent crossover trial, methylphenidate treatment decreased apathy in Alzheimer’s disease. We further assessed this finding in the Apathy in Dementia Methylphenidate Trial (ADMET). Method: Six-week, randomized, double-blind, placebo-controlled multicenter trial enrolling Alzheimer’s disease participants (NINCDS-ADRDA criteria) with apathy assigned to methylphenidate 20 mg daily or placebo, conducted from June 2010 to December […]

Leontjevas, Ruslan, Teerenstra, Steven, Smalbrugge, Martin, Vernooij-Dassen, Myrra J. F. J., Bohlmeijer, Ernst T., Gerritsen, Debby L, Koopmans, Raymond T. C. M.

Background: Apathy is common in nursing home (NH) residents and it overlaps with depression. This study examines the effects of a multidisciplinary depression program on apathy and depressive motivational and mood symptoms.; Methods: Secondary analyses of a stepped-wedge cluster-randomized controlled trial were conducted with six measurements. Sixteen dementia NH units and 17 somatic units were […]

Leone, Elsa, Deudon, Audrey, Bauchet, Murielle, Laye, Mathilde, Bordone, Nathalie, Lee, Ji-Hyun, Piano, Julie, Friedman, Leah, David, Renaud, Delva, Fleur, Brocker, Patrice, Yesavage, Jerome, Robert, Philippe Henri

Objective: This study aimed to evaluate the effectiveness of a nursing home (NH) staff education to manage apathy in older individuals with a diagnosis of dementia.; Methods: Sixteen NHs agreed to participate, and 230 demented apathetic residents were randomly assigned to the reference group (RG) or the intervention group (IG). IG received a month of […]

Lanctôt, Krista L., Chau, Sarah A., Herrmann, Nathan, Drye, Lea T., Rosenberg, Paul B., Scherer, Roberta W., Black, Sandra E., Vaidya, Vijay, Bachman, David L., Mintzer, Jacobo E.

Background: Little is known about the effect of methylphenidate (MPH) on attention in Alzheimer’s disease (AD). MPH has shown to improve apathy in AD, and both apathy and attention have been related to dopaminergic function. The goal was to investigate MPH effects on attention in AD and assess the relationship between attention and apathy responses.; […]

Delphin-Combe, Floriane, Rouch, Isabelle, Martin-Gaujard, Géraldine, Relland, Solveig, Krolak-Salmon, Pierre

An innovative non-pharmacological intervention called Voix d’Or(®) (Golden Voice) was proposed in the Cognitive behavioral unit (CBU) of the Memory center at the Hospices civils in Lyon. Voix d’Or(®) offers eight sound activities disseminated via an audio device based on different approaches sociotherapeutic (music therapy, reminiscence, relaxation, reorientation in reality). The aim of this study […]