Munro, Cynthia A., Longmire, Crystal Flynn, Drye, Lea T., Martin, Barbara K., Frangakis, Constantine E., Meinert, Curtis L., Mintzer, Jacobo E., Porsteinsson, Anton P., Rabins, Peter V., Rosenberg, Paul B., Schneider, Lon S., Weintraub, Daniel, Lyketsos, Constantine G.

Objectives: Although many depressed patients with Alzheimer disease (AD) are treated with antidepressants, the effect of such treatment on cognitive performance in these patients is not known. The authors report cognitive outcomes in patients with depression of AD (dAD) after a 24-week trial of sertraline or placebo.; Design: Placebo-controlled, randomized, double-blind trial.; Setting: Outpatient memory […]

Kurz, Alexander, Wagenpfeil, Stefan, Hallauer, Johannes, Schneider-Schelte, Helga, Jansen, Sabine

Objective: To evaluate the efficacy of a practical, easily implemented, educational intervention in group format for informal carers of persons with dementia.; Methods: Multi-centre, randomised, controlled, single-blind trial involving 292 family caregivers of patients with moderate dementia in Alzheimer’s disease.; Results: Participants valued program components which had a practical impact on their caring role. The […]

Meeuwsen, Els, Melis, René, van der Aa, Geert, Golüke-Willemse, Gertie, de Leest, Benoit, van Raak, Frank, Schölzel-Dorenbos, Carla, Verheijen, Desiree, Verhey, Frans, Visser, Marieke, Wolfs, Claire, Adang, Eddy, Olde Rikkert, Marcel

Objective: To evaluate the cost-effectiveness of post-diagnosis dementia treatment and coordination of care by memory clinics compared to general practitioners’ care.; Methods: A multicentre randomised trial with 175 community dwelling patients newly diagnosed with mild to moderate dementia, and their informal caregivers, with twelve months’ follow-up. Cost-effectiveness was evaluated from a societal point of view […]