This database contains 524 studies, archived under the term: "alzheimer disease"
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Effects of the Finnish Alzheimer disease exercise trial (FINALEX): a randomized controlled trial
Pitkälä, Kaisu H.,
Pöysti, Minna M.,
Laakkonen, Marja-Liisa,
Tilvis, Reijo S.,
Savikko, Niina,
Kautiainen, Hannu,
Strandberg, Timo E.
Importance: Few rigorous clinical trials have investigated the effectiveness of exercise on the physical functioning of patients with Alzheimer disease (AD).; Objectives: To investigate the effects of intense and long-term exercise on the physical functioning and mobility of home-dwelling patients with AD and to explore its effects on the use and costs of health and […]
Video prompting versus other instruction strategies for persons with Alzheimer’s disease
Perilli, V.,
Lancioni, G. E.,
Hoogeveen, F.,
Caffo, A.,
Singh, N.,
O'Reilly, M.,
Sigafoos, J.,
Cassano, G.,
Oliva, D.
Background/aim: Two studies assessed the effectiveness of video prompting as a strategy to support persons with mild and moderate Alzheimer’s disease in performing daily activities.; Methods: In study I, video prompting was compared to an existing strategy relying on verbal instructions. In study II, video prompting was compared to another existing strategy relying on static […]
Peaceful Mind: an open trial of cognitive-behavioral therapy for anxiety in persons with dementia
Paukert, Amber L.,
Calleo, Jessica,
Kraus-Schuman, Cynthia,
Snow, Lynn,
Wilson, Nancy,
Petersen, Nancy J.,
Kunik, Mark E.,
Stanley, Melinda A.
Background: Anxiety has a high prevalence among individuals with dementia, and it has a significant negative impact on their functioning; yet intervention studies are lacking. We developed Peaceful Mind, a cognitive-behavioral intervention for persons with dementia. In this paper, we describe the intervention and results of an open trial evaluating the feasibility and utility of […]
Impact of molecular imaging on the diagnostic process in a memory clinic
Ossenkoppele, Rik,
Prins, Niels D.,
Pijnenburg, Yolande A.L.,
Lemstra, Afina W.,
van der Flier, Wiesje M.,
Adriaanse, Sofie F.,
Windhorst, Albert D.,
Handels, Ron L.H.,
Wolfs, Claire A.G.,
Aalten, Pauline,
Verhey, Frans R.J.,
Verbeek, Marcel M.,
van Buchem, Mark A.,
Hoekstra, Otto S.,
Lammertsma, Adriaan A.,
Scheltens, Philip,
van Berckel, Bart N.M.
Background: [(11)C]Pittsburgh compound B ([(11)C]PIB) and [(18)F]-2-fluoro-2-deoxy-D-glucose ([(18)F]FDG) PET measure fibrillar amyloid-β load and glucose metabolism, respectively. We evaluated the impact of these tracers on the diagnostic process in a memory clinic population.; Methods: One hundred fifty-four patients underwent paired dynamic [(11)C]PIB and static [(18)F]FDG PET scans shortly after completing a standard dementia screening. Two-year […]
Motor effects of REAC in advanced Alzheimer’s disease: results from a pilot trial
Olazarán, Javier,
González, Belén,
López-Álvarez, Jorge,
Castagna, Alessandro,
Osa-Ruiz, Emma,
Herrero-Cano, Vanesa,
Agüera-Ortiz, Luis,
Rinaldi, Salvatore,
Martínez-Martín, Pablo
We conducted a pilot, randomized, controlled trial to mainly investigate the feasibility, safety, and short-term motor effects of brain stimulation with radio electric asymmetric conveyer (REAC) technology in patients with advanced Alzheimer’s disease (AD) who also experience some gait dysfunction. Neuropostural optimization (NPO) or sham protocol was administered to 31 nursing home patients (mean [SD] […]
The prediction of response to galantamine treatment in patients with mild to moderate Alzheimer’s disease
Ohnishi, Takashi,
Sakiyama, Yojiro,
Okuri, Yuichi,
Kimura, Yuji,
Sugiyama, Nami,
Saito, Takayuki,
Takahashi, Masayoshi,
Kobayashi, Takumi
The prediction of efficacy in long-term treatment of acetylcholinesterase inhibitors (AChEIs) is a major clinical issue, although no consistently strong predictive factors have emerged thus far. The present analyses aimed to identify factors for predicting long-term outcome of galantamine treatment. Analyses were conducted with data from a 24 weeks randomized, double-blind, placebo controlled trial to […]
Effects of centrally acting angiotensin converting enzyme inhibitors on functional decline in patients with Alzheimer’s disease
O'Caoimh, Rónán,
Healy, Liam,
Gao, Yang,
Svendrovski, Anton,
Kerins, David M.,
Eustace, Joseph,
Kehoe, Patrick Gavin,
Guyatt, Gordon,
Molloy, D. William
Background: Centrally acting angiotensin converting enzyme inhibitors (CACE-Is) are associated with reduced rates of cognitive decline in patients with dementia. CACE-Is may also improve exercise tolerance in functionally impaired older adults with normal cognition, suggesting that CACE-Is may positively influence activities of daily living (ADL) in dementia.; Objective: To compare rates of decline in patients […]